Department of Nutrition, Food Sciences and Gastronomy, XIA, School of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain.
INSA-UB, Nutrition and Food Safety Research Institute, University of Barcelona, Santa Coloma de Gramanet, Spain.
J Sci Food Agric. 2023 Dec;103(15):7506-7516. doi: 10.1002/jsfa.12826. Epub 2023 Jul 28.
The main aim of this 2-year non-randomized parallel controlled clinical pilot trial was to evaluate the long-term effect of a moderate daily intake of beer (with and without alcohol) on cardiovascular health in postmenopausal women. A total of 34 participants were grouped into three study arms: 16 were administered alcoholic beer, 6 consumed non-alcoholic beer, and 12 were in the control group. Changes in glucose metabolism, lipid profile, liver enzymes, anthropometric measurements, body composition, and blood pressure variables were monitored. Data on medical history, diet, and exercise were collected, and gustatory capacities were determined.
Moderate consumption of beer, both alcoholic and non-alcoholic, seemed to have positive effects on biochemical indicators of cardiovascular health in postmenopausal women, with 660 mL day of non-alcoholic beer reducing low-density lipoprotein cholesterol blood levels, and 330 mL day of alcoholic beer increasing high-density lipoprotein cholesterol. The evolution of changes in android and gynoid fat percentage and their ratio differed significantly between study groups, which was attributable to either the interventions or the disparity between groups regarding the time elapsed since menopause onset. Iso-α-acids recognition threshold could be involved in intervention group election, whereas the sensory phenotypes studied were not associated with alcohol drinking frequency.
Moderate beer consumption was found to improve the lipid profile of postmenopausal women, although their effects in preventing cardiometabolic alterations deserve further research (trial registration number: ISRCTN13825020; https://doi.org/10.1186/ISRCTN13825020). © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
本为期 2 年的非随机平行对照临床初步试验的主要目的是评估适量日常摄入啤酒（含酒精和不含酒精）对绝经后妇女心血管健康的长期影响。共有 34 名参与者分为三组：16 人饮用含酒精啤酒，6 人饮用无酒精啤酒，12 人作为对照组。监测葡萄糖代谢、血脂谱、肝酶、人体测量、身体成分和血压变量的变化。收集了有关病史、饮食和运动的数据，并测定了味觉能力。
适量饮用啤酒，包括含酒精和无酒精啤酒，似乎对绝经后妇女心血管健康的生化指标有积极影响，每天饮用 660 毫升无酒精啤酒可降低低密度脂蛋白胆固醇水平，每天饮用 330 毫升含酒精啤酒可增加高密度脂蛋白胆固醇。安卓和女性脂肪百分比及其比值的变化趋势在不同组之间存在显著差异，这归因于干预措施或绝经后时间间隔导致的组间差异。异-α-酸识别阈值可能与干预组的选择有关，而研究的感官表型与饮酒频率无关。
适量饮用啤酒可改善绝经后妇女的血脂谱，但它们在预防心血管代谢变化方面的作用仍需要进一步研究（试验注册号：ISRCTN13825020；https://doi.org/10.1186/ISRCTN13825020）。© 2023 作者。《食品科学杂志》由 John Wiley & Sons Ltd 代表化学工业协会出版。
