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复方太子参颗粒通过调节肠道菌群和氨基酸代谢减轻化疗所致的肠道黏膜炎

Fufang Taizishen Granules Attenuate Chemotherapy-Induced Intestinal Mucositis by Modulating Gut Microbiota and Amino Acid Metabolism.

作者信息

Kan Yongjun, Liu Yingying, Zhao Li, Jiang Chang, Pang Wensheng, Zhang Bianhong, Lin Wenxiong, Hu Juan

机构信息

Fujian Academy of Chinese Medical Sciences Fuzhou P.R. China.

The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine Fuzhou P.R. China.

出版信息

Food Sci Nutr. 2025 Aug 11;13(8):e70789. doi: 10.1002/fsn3.70789. eCollection 2025 Aug.

DOI:10.1002/fsn3.70789
PMID:40801049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12339415/
Abstract

Chemotherapy-induced intestinal mucositis is a severe adverse effect affecting cancer patients, and there are currently no effective strategies for its prevention. Fufang Taizishen granules (FFTZS), a traditional Chinese medicine (TCM) known for its anti-inflammatory, anti-fatigue, and immunostimulatory properties, have shown therapeutic potential. However, the effects of FFTZS on chemotherapy-induced intestinal mucositis and its underlying mechanisms remain unclear. A mouse model of intestinal mucositis was induced using 5-FU and irinotecan to assess the protective effects of FFTZS. The study found that FFTZS enhanced food intake, reduced diarrhea index, and improved histopathological damage in colonic tissues. FFTZS also reduced inflammatory cell infiltration and inhibited apoptosis. Moreover, FFTZS treatment increased the expression of Claudin-1 and ZO-1 proteins. Microbial analysis revealed an enrichment of beneficial bacteria and a reduction of opportunistic pathogens, whereas metabolomic analysis showed that FFTZS corrected amino acid metabolic disturbances induced by chemotherapy. These findings suggest that FFTZS mitigates chemotherapy-induced intestinal mucositis by preserving mucosal integrity, modulating gut microbiota, and restoring metabolic homeostasis.

摘要

化疗引起的肠道黏膜炎是影响癌症患者的一种严重不良反应，目前尚无有效的预防策略。复方太子参颗粒（FFTZS）是一种以抗炎、抗疲劳和免疫刺激特性而闻名的中药，已显示出治疗潜力。然而，FFTZS对化疗引起的肠道黏膜炎的影响及其潜在机制仍不清楚。使用5-氟尿嘧啶和伊立替康诱导建立肠道黏膜炎小鼠模型，以评估FFTZS的保护作用。研究发现，FFTZS增加了食物摄入量，降低了腹泻指数，并改善了结肠组织的组织病理学损伤。FFTZS还减少了炎症细胞浸润并抑制了细胞凋亡。此外，FFTZS治疗增加了Claudin-1和ZO-1蛋白的表达。微生物分析显示有益菌富集，机会致病菌减少，而代谢组学分析表明FFTZS纠正了化疗引起的氨基酸代谢紊乱。这些发现表明，FFTZS通过维持黏膜完整性、调节肠道微生物群和恢复代谢稳态来减轻化疗引起的肠道黏膜炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/674b745e35cc/FSN3-13-e70789-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/7b4c01976ef4/FSN3-13-e70789-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/fd28929dc456/FSN3-13-e70789-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/1781e70aaa9c/FSN3-13-e70789-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/74e757a41cf8/FSN3-13-e70789-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/08fed853c987/FSN3-13-e70789-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/48eb708cd420/FSN3-13-e70789-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/38b9dc0a03fa/FSN3-13-e70789-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/354b949a008b/FSN3-13-e70789-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/569c20fda874/FSN3-13-e70789-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/674b745e35cc/FSN3-13-e70789-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/7b4c01976ef4/FSN3-13-e70789-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/fd28929dc456/FSN3-13-e70789-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/1781e70aaa9c/FSN3-13-e70789-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/74e757a41cf8/FSN3-13-e70789-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/08fed853c987/FSN3-13-e70789-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/48eb708cd420/FSN3-13-e70789-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/38b9dc0a03fa/FSN3-13-e70789-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/354b949a008b/FSN3-13-e70789-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/569c20fda874/FSN3-13-e70789-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4208/12339415/674b745e35cc/FSN3-13-e70789-g001.jpg

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本文引用的文献

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Cell Mol Gastroenterol Hepatol. 2025;19(2):101423. doi: 10.1016/j.jcmgh.2024.101423. Epub 2024 Oct 24.
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The influence of Akkermansia muciniphila on intestinal barrier function.嗜黏蛋白阿克曼氏菌对肠道屏障功能的影响。
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Alginate oligosaccharide improves 5-fluorouracil-induced intestinal mucositis by enhancing intestinal barrier and modulating intestinal levels of butyrate and isovalerate.
海藻糖寡糖通过增强肠道屏障和调节肠道中丁酸盐和异戊酸盐的水平来改善 5-氟尿嘧啶诱导的肠道黏膜炎。
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Vitamins and fatty acids against chemotherapy-induced intestinal mucositis.维生素和脂肪酸防治化疗引起的肠道黏膜炎。
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Compound prebiotics as prophylactic and adjunctive treatments ameliorate DSS-induced colitis through gut microbiota modulation effects.复合益生元作为预防性和辅助性治疗手段，通过调节肠道微生物群的作用改善葡聚糖硫酸钠（DSS）诱导的结肠炎。
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The Predictive Value of Serum DAO, HDC, and MMP8 for the Gastrointestinal Injury in the Early Stage of Acute Pancreatitis in an Animal Model and a Clinical Study.血清二胺氧化酶、组胺脱羧酶和基质金属蛋白酶8在急性胰腺炎动物模型及临床研究早期对胃肠道损伤的预测价值
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