乳酸/白蛋白比值和NEWS-乳酸在预测脓毒症相关性急性肾损伤中的预后价值：一项回顾性分析
Prognostic Value of Lactate/Albumin Ratio and NEWS-Lactate in Predicting Sepsis-Associated Acute Kidney Injury: A Retrospective Analysis.
作者信息
Le Xuan Duong, Nguyen Hai Ghi, Vu Anh Duc, Do Thanh Hoa
机构信息
108 Military Central Hospital, Hanoi, Vietnam.
出版信息
Arch Acad Emerg Med. 2025 Jul 1;13(1):e61. doi: 10.22037/aaemj.v13i1.2723. eCollection 2025.
INTRODUCTION
Sepsis-associated acute kidney injury (SA-AKI) is a frequent complication in critically ill patients and is associated with increased mortality. This study aimed to evaluate the prognostic value of the lactate/albumin ratio (LAR) and other albumin-based biomarkers in predicting SA-AKI.
METHODS
A retrospective observational study was conducted on 564 patients with sepsis, divided into two groups based on the presence (n = 298) or absence (n = 266) of AKI. Clinical characteristics, laboratory parameters, and disease severity scores (SOFA, APACHE II, NEWS, NEWS-Lactate) were compared between groups. The predictive performance of each marker in detecting SA-AKI was assessed using receiver operating characteristic (ROC) curve analysis.
RESULTS
serum creatinine/albumin ratio (sCAR), blood urea nitrogen/albumin ratio (BAR), and procalcitonin/albumin ratio (PAR) procalcitonin (PCT)
CONCLUSION
It seems that, t for early detection of SA-AKI and may outperform conventional severity scores and standalone laboratory parameters.
引言
脓毒症相关急性肾损伤（SA - AKI）是重症患者常见的并发症，且与死亡率增加相关。本研究旨在评估乳酸/白蛋白比值（LAR）及其他基于白蛋白的生物标志物在预测SA - AKI方面的预后价值。
方法
对564例脓毒症患者进行回顾性观察研究，根据是否存在急性肾损伤（AKI）分为两组（存在AKI组，n = 298；不存在AKI组，n = 266）。比较两组间的临床特征、实验室参数及疾病严重程度评分（序贯器官衰竭评估（SOFA）、急性生理与慢性健康状况评分系统II（APACHE II）、国家早期预警评分（NEWS）、含乳酸的国家早期预警评分（NEWS - Lactate））。使用受试者工作特征（ROC）曲线分析评估每个标志物检测SA - AKI的预测性能。
结果
血清肌酐/白蛋白比值（sCAR）、血尿素氮/白蛋白比值（BAR）及降钙素原/白蛋白比值（PAR）、降钙素原（PCT）
结论
似乎，t用于SA - AKI的早期检测，可能优于传统的严重程度评分及单独的实验室参数。
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