Department of Laboratory Medicine, Peking University Third Hospital, Beijing, China.
Core Unit of National Clinical Research Center for Laboratory Medicine, Peking University Third Hospital, Beijing, China.
Front Immunol. 2022 Jul 7;13:905601. doi: 10.3389/fimmu.2022.905601. eCollection 2022.
Sepsis-associated acute kidney injury (SA-AKI) is a common complication in critically ill patients with high morbidity and mortality. SA-AKI varies considerably in disease presentation, progression, and response to treatment, highlighting the heterogeneity of the underlying biological mechanisms. In this review, we briefly describe the pathophysiology of SA-AKI, biomarkers, reference databases, and available omics techniques. Advances in omics technology allow for comprehensive analysis of SA-AKI, and the integration of multiple omics provides an opportunity to understand the information flow behind the disease. These approaches will drive a shift in current paradigms for the prevention, diagnosis, and staging and provide the renal community with significant advances in precision medicine in SA-AKI analysis.
脓毒症相关性急性肾损伤（SA-AKI）是危重病患者的常见并发症，具有较高的发病率和死亡率。SA-AKI 在疾病表现、进展和治疗反应方面存在很大差异，突出了潜在生物学机制的异质性。在这篇综述中，我们简要描述了 SA-AKI 的病理生理学、生物标志物、参考数据库和现有的组学技术。组学技术的进步使得对 SA-AKI 的全面分析成为可能，而多种组学的整合为理解疾病背后的信息流提供了机会。这些方法将推动当前预防、诊断和分期的范式转变，并为肾脏领域在 SA-AKI 分析中的精准医学提供重大进展。
