Khadri D, Mahir E M, Ouattassi N, Bouchal S, Chtaou N, El Midaoui A, Tachfouti N, Belahsen M F
Laboratory of Epidemiology and Health Sciences Research, Faculty of Medicine, Pharmacy and Dentistry, Sidi Mohammed Ben Abdallah University, Fez, Morocco.
Otolaryngology, Head and Neck Surgery Department, Hassan II University Hospital, Fez, Morocco.
Neurodegener Dis Manag. 2025 Aug 13:1-10. doi: 10.1080/17582024.2025.2542667.
Parkinson's Disease (PD) is the second most common neurodegenerative disorder. Hypokinetic dysarthria, a motor speech disorder affects approximately 90% of PD patients. In Morocco, linguistic features of Moroccan Arabic may influence how voice impairment appear in PD. This study investigates the acoustic characteristics of Moroccan PD patients' voices. This was a case-control study involving 30 Moroccan PD patients, both medicated and unmedicated) and 30 healthy control participants. Voice recordings were collected from participants before and after dopaminergic treatment. Four tasks were performed: sustained vowel production, spontaneous speech, diadochokinesis, and reading tasks in both Arabic and French. The Unified Parkinson's Disease Rating Scale was computed for each state and data were analyzed using PRAAT software (v6.2), for phonatory and articulatory parameters. PD patients exhibited significant alterations in shimmer, jitter, and Harmonics-to-Noise and Noise-to-Harmonic Ratios, reflecting pitch and vocal intensity instability. A "hoarse" and "breathy" vocal quality was noted. Rhythm disturbances were marked by an increased number of long pauses (≥500 ms), indicating difficulty in sustaining speech flow. No adverse events were reported. Moroccan PD patients exhibit distinctive voice and rhythm abnormalities, particularly in vowel articulation, phonation, and timing. These markers may serve as reliable indicators for PD diagnosis and progression.
帕金森病（PD）是第二常见的神经退行性疾病。运动性言语障碍——运动迟缓性构音障碍影响约90%的帕金森病患者。在摩洛哥，摩洛哥阿拉伯语的语言特征可能会影响帕金森病患者声音障碍的表现形式。本研究调查了摩洛哥帕金森病患者声音的声学特征。这是一项病例对照研究，涉及30名摩洛哥帕金森病患者（包括正在服药和未服药的）以及30名健康对照参与者。在多巴胺能治疗前后收集参与者的语音记录。进行了四项任务：持续元音发音、自发言语、连续重复运动以及阿拉伯语和法语的阅读任务。针对每种状态计算统一帕金森病评定量表，并使用PRAAT软件（v6.2）分析数据，以获取发声和发音参数。帕金森病患者在声门颤动、基频微扰以及谐波与噪声比和噪声与谐波比方面表现出显著变化，反映出音高和声音强度的不稳定。注意到一种“嘶哑”和“呼吸声重”的嗓音质量。节奏紊乱的特征是长停顿（≥500毫秒）的数量增加，表明维持言语流畅存在困难。未报告不良事件。摩洛哥帕金森病患者表现出独特的声音和节奏异常，尤其是在元音发音、发声和时间控制方面。这些指标可作为帕金森病诊断和病情进展的可靠指标。
