Ebnet Klaus, Aurrand-Lions Michel
Institute-associated Research Group "Cell adhesion and cell polarity", Institute of Medical Biochemistry, ZMBE, University of Muenster, Von-Esmarch-Str. 56, D-48149, Muenster, Germany.
Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM Equipe Labellisée, Ligue, Marseille, 2020, France.
Cell Mol Life Sci. 2025 Aug 13;82(1):312. doi: 10.1007/s00018-025-05829-z.
Junctional Adhesion Molecule-C (JAM-C) is a member of the JAM family of cell adhesion molecules. JAM-C is expressed by a large variety of tissues including epithelial and endothelial tissues, neuronal tissues, glial cells, cells of the reproductive system, or cells of the hematopoietic system. Through trans-homophilic as well as trans-heterophilic interactions with the JAM family member JAM-B and with members of the integrin family JAM-C regulates diverse processes including epithelial barrier formation, leukocyte- endothelial interactions and transendothelial migration, neuronal cell migration along glial fibers, myelin sheath integrity, and germ cell migration. In this article, we review the biological activities of JAM-C, including its basic organization, its extracellular and intracellular interaction partners, and its diverse physiological functions.
连接黏附分子C（JAM-C）是细胞黏附分子JAM家族的成员。JAM-C在多种组织中表达，包括上皮组织、内皮组织、神经组织、神经胶质细胞、生殖系统细胞或造血系统细胞。通过与JAM家族成员JAM-B以及整合素家族成员进行同源性和异源性相互作用，JAM-C调节多种过程，包括上皮屏障形成、白细胞-内皮细胞相互作用和跨内皮迁移、神经细胞沿神经胶质纤维的迁移、髓鞘完整性以及生殖细胞迁移。在本文中，我们综述了JAM-C的生物学活性，包括其基本结构、细胞外和细胞内相互作用伙伴以及其多样的生理功能。
