Wu Xiao, Fang Ke, Huang Wenya, Chen Gang, Wang Dingkun
Department of Integrated Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Cancer Res Clin Oncol. 2025 Aug 13;151(8):230. doi: 10.1007/s00432-025-06283-x.
Combined small-cell lung carcinoma (C-SCLC) is an uncommon lung cancer variant characterized by the presence of multiple pathological types within a single case or tumor, typically associated with poor outcomes. The high rate of misdiagnosis and low rate of accurate diagnosis for C-SCLC stem from limitations in sample collection, which primarily involves bronchoscopy and aspiration biopsy instead of surgical resection or autopsy. Moreover, standard chemotherapy for patients with C-SCLC has not yet been established. Cases of combined small-cell lung cancer with adenocarcinoma are extremely rare. Herein, we report a case of the detailed whole-process treatment of combined small-cell lung cancer with adenocarcinoma and review the literature.
混合性小细胞肺癌（C-SCLC）是一种罕见的肺癌变体，其特征是在单个病例或肿瘤中存在多种病理类型，通常预后较差。C-SCLC的高误诊率和低准确诊断率源于样本采集的局限性，样本采集主要涉及支气管镜检查和穿刺活检，而非手术切除或尸检。此外，C-SCLC患者的标准化化疗方案尚未确立。小细胞肺癌合并腺癌的病例极为罕见。在此，我们报告一例小细胞肺癌合并腺癌的详细全程治疗病例并进行文献复习。
