Smith Edward, Langdon Dawn
Department of Psychology, Royal Holloway University of London, Egham, UK.
Neurol Ther. 2025 Aug 13. doi: 10.1007/s40120-025-00806-x.
The effectiveness of disease-modifying therapies (DMTs) in managing MS has been established, although adherence is commonly difficult to achieve, which can undermine health outcomes. People with MS (pwMS) who perceive greater benefits from DMTs are more likely to report being adherent. This pilot study investigated the extent to which knowledge of MS and its risks contributes to this relationship. Knowledge is modifiable and may enhance adherence.
Sixty-three pwMS were recruited through MS charity webpages and social media to take part in an anonymous online survey including validated measures of perceived adherence benefits, perceived MS susceptibility, MS knowledge, MS risk knowledge and self-reported treatment adherence.
In a hierarchical regression, greater perceived treatment adherence benefit was significantly associated with higher levels of self-reported adherence (B = 0.20, β = 0.27, t(59) = 2.16, p = 0.04). Interestingly, adding objective measures of MS knowledge F(2,61) = 0.96, p = 0.33) and subsequently MS risk knowledge (F(3,59) = 2.29, p = 0.14) did not significantly change variance in self-reported adherence.
An individual's subjective evaluation of DMT benefits seems to be a key driver in treatment adherence, possibly reflecting the individual and cultural context. Interventions which centre on patient perceived benefit may be more effective in supporting adherence.
尽管疾病修饰疗法（DMTs）在治疗多发性硬化症（MS）方面的有效性已得到证实，但患者通常难以坚持治疗，这可能会影响治疗效果。认为DMTs益处更大的MS患者更有可能报告坚持治疗。这项初步研究调查了MS知识及其风险在这种关系中所起作用的程度。知识是可以改变的，可能会提高治疗依从性。
通过MS慈善网页和社交媒体招募了63名MS患者，参与一项匿名在线调查，调查内容包括对感知到的依从性益处、感知到的MS易感性、MS知识、MS风险知识以及自我报告的治疗依从性的有效测量。
在分层回归中，更高的感知治疗依从性益处与更高水平的自我报告依从性显著相关（B = 0.20，β = 0.27，t(59) = 2.16，p = 0.04）。有趣的是，加入MS知识的客观测量指标（F(2,61) = 0.96，p = 0.33）以及随后的MS风险知识（F(3,59) = 2.29，p = 0.14）并没有显著改变自我报告依从性的方差。
个体对DMT益处的主观评估似乎是治疗依从性的关键驱动因素，这可能反映了个体和文化背景。以患者感知到的益处为中心的干预措施可能在支持依从性方面更有效。
