纳洛酮对针刺抑制人体振动诱发抓握反射的拮抗作用。
The antagonistic effects of naloxone on acupuncture inhibition of the vibration-induced grasp reflex in man.
作者信息
Homma S, Hori Y, Yonezawa T
出版信息
Neurosci Lett. 1985 Oct 24;61(1-2):227-32. doi: 10.1016/0304-3940(85)90429-x.
It is known that the vibration-induced grasp reflex (VGR) is inhibited by the insertion of needles into the acupuncture points. Effects of intravenous administration of naloxone on acupuncture inhibition of the VGR were studied in human subjects to determine if acupuncture inhibition of the VGR might be mediated by endogenous opioids. Acupuncture inhibition of the VGR was partly reversed by the administration of naloxone. The VGR is mediated by a polysynaptic pathway through which the acupuncture inhibition that is reversed by naloxone is considered to occur. We conclude that the facilitatory influence of interneurons on motoneurons in the VGR was reduced by endogenous opioids to inhibit the VGR.
众所周知，针刺穴位可抑制振动诱发的抓握反射（VGR）。在人体受试者中研究了静脉注射纳洛酮对针刺抑制VGR的影响，以确定针刺对VGR的抑制作用是否可能由内源性阿片类物质介导。纳洛酮给药部分逆转了针刺对VGR的抑制作用。VGR由多突触通路介导，纳洛酮逆转的针刺抑制作用被认为是通过该通路发生的。我们得出结论，内源性阿片类物质降低了中间神经元对VGR中运动神经元的促进作用，从而抑制了VGR。
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