Lu Mingzhu, Ding Yangkun
Department of Pediatric Orthopaedics, Jinan Children's Hospital, Jinan, China.
PLoS One. 2025 Aug 13;20(8):e0330064. doi: 10.1371/journal.pone.0330064. eCollection 2025.
Osteoarthritis (OA) and gastrointestinal diseases are two significant public health problems. However, the association between the two is unclear. This study aimed to investigate the biological relationship between gastrointestinal diseases and OA using data derived from the National Health and Nutrition Examination Survey (NHANES) database. A total of 8,833 participants registered in the NHANES between 2011 and 2018 were enrolled; 5,044 participants were included in the study after excluding ineligible samples. Three models were constructed to investigate the correlation between gastrointestinal diseases and OA. Risk stratification analysis was conducted, and a receiver operating characteristic (ROC) curve was employed. Among 5,044 participants, even after stratification, gastrointestinal diseases significantly affected OA occurrence; this effect persisted despite adjusting for all covariates in model 3 (odds ratio = 2.01; 95% confidence interval = 1.23-3.3, p = 0.0069) and was confirmed by risk-stratification analysis. The ROC curve and the smooth curve showed that gastrointestinal diseases increased OA risk. Gastrointestinal diseases are significant risk factors for OA, which indicates a potential theoretical basis for OA prevention.
骨关节炎（OA）和胃肠道疾病是两个重大的公共卫生问题。然而，两者之间的关联尚不清楚。本研究旨在利用来自美国国家健康与营养检查调查（NHANES）数据库的数据，调查胃肠道疾病与OA之间的生物学关系。共有8833名在2011年至2018年期间登记参加NHANES的参与者被纳入研究；在排除不合格样本后，5044名参与者被纳入本研究。构建了三个模型来研究胃肠道疾病与OA之间的相关性。进行了风险分层分析，并采用了受试者工作特征（ROC）曲线。在5044名参与者中，即使经过分层，胃肠道疾病仍显著影响OA的发生；在模型3中对所有协变量进行调整后，这种影响仍然存在（优势比=2.01；95%置信区间=1.23-3.3，p=0.0069），并通过风险分层分析得到证实。ROC曲线和平滑曲线表明，胃肠道疾病增加了OA风险。胃肠道疾病是OA的重要风险因素，这为OA的预防提供了潜在的理论依据。
