Heilongjiang University of Chinese Medicine, Harbin, China.
First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.
Medicine (Baltimore). 2024 Sep 27;103(39):e39814. doi: 10.1097/MD.0000000000039814.
The gut microbiota and inflammatory proteins may affect the development of peptic ulcer disease. However, this association remains unclear. We analyzed genome-wide association study data of gut microbiota, inflammatory proteins, and peptic ulcer disease using Mendelian randomization with instrumental variables to assess causal relationships. Various statistical methods, including inverse variance weighting, Mendelian randomization Egger regression, and sensitivity analysis were employed to evaluate the data and calculate mediation ratios. Our findings reveal that the genus Butyriciccus plays a role in mitigating the adverse effects of gastric ulcers by 7.9%, primarily through reducing beta-negative growth factor levels. Additionally, the genus Lachnospiraceae UCG004 can significantly alleviate the negative outcomes of gastric ulcers and reduces hepatocyte growth factor and beta-reserve growth factor levels by 6.39% and 7.45%, respectively. This study highlights the independent and mediating effects of the gut microbiota and inflammatory proteins on peptic ulcers, offering insights on potential pathways and targets for future preventive interventions.
肠道微生物群和炎症蛋白可能会影响消化性溃疡的发展。然而，这种关联尚不清楚。我们使用基于工具变量的孟德尔随机化分析了肠道微生物群、炎症蛋白和消化性溃疡的全基因组关联研究数据，以评估因果关系。采用了多种统计方法，包括逆方差加权、孟德尔随机化 Egger 回归和敏感性分析来评估数据并计算中介比率。我们的研究结果表明，丁酸杆菌属通过降低β-阴性生长因子水平，对胃溃疡的不良影响减轻 7.9%。此外，毛螺菌科 UCG004 可以显著减轻胃溃疡的不良后果，分别降低肝细胞生长因子和β-储备生长因子水平 6.39%和 7.45%。本研究强调了肠道微生物群和炎症蛋白对消化性溃疡的独立和中介作用，为未来的预防干预提供了潜在的途径和靶点。
