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三级医疗中心肾内科就诊的糖尿病患者微量白蛋白尿:一项描述性横断面研究。

Microalbuminuria among Patients with Diabetes Mellitus Visiting the Department of Nephrology in a Tertiary Care Centre: A Descriptive Cross-sectional Study.

作者信息

Bhattarai Tulsi, Pandey Asim, Parajuli Samriddhi, Khanal Prajwal, Dongol Angel, Devkota Rahul, Neupane Sohil, Bhattarai Bharat Kumar

机构信息

Department of Nephrology, National Academy of Medical Sciences, Bir Hospital, Mahaboudha, Kathmandu, Nepal.

Department of Cardiology, Norvic International Hospital, Thapathali, Kathmandu, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2023 Jul;61(263):596-598. doi: 10.31729/jnma.8214. Epub 2023 Jul 30.


DOI:10.31729/jnma.8214
PMID:40802713
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10395572/
Abstract

INTRODUCTION: Microalbuminuria is an abnormal increase in albumin excretion rate with a specific range of 30-299 mg of albumin/g of creatinine or excretion of 20-200 mg/l of albumin in spot urine samples. Diabetic patients with microalbuminuria are at increased risk for cardiovascular death as compared with normoalbuminuria. The aim of this study was to find out the prevalence of microalbuminuria among patients visiting the Department of Nephrology in a tertiary care centre. METHOD: This is a descriptive cross-sectional study conducted among diabetic patients visiting the Department of Nephrology in a tertiary care centre after obtaining ethical approval from the Institutional Review Committee (Reference number: 04072022/04). The study was conducted between 1 October 2022 to 30 November 2022 where patients providing written consent and had documented diabetes were included in the study whereas patients without documented diabetes, having comorbidities such as congestive heart failure, nephritic/nephrotic syndrome and those who refused to give consent were excluded from the study. Convenience sampling was done. Point estimate and 95% Confidence Interval were calculated. RESULTS: Among 103 patients, microalbuminuria was found to be in 19 (18.45%) (10.96-25.94, 95% Confidence Interval). Out of 19 patients, 8 (42.11%) were male and 11 (57.89%) were female. The mean HbA1c among participants with microalbuminuria was 7.67±0.67%. CONCLUSIONS: The prevalence of microalbuminuria among diabetic patients was similar to other studies done in similar settings.

摘要

引言:微量白蛋白尿是指白蛋白排泄率异常增加,随机尿样中白蛋白排泄率范围为30 - 299毫克/克肌酐或20 - 200毫克/升白蛋白。与正常白蛋白尿的糖尿病患者相比,微量白蛋白尿患者心血管死亡风险增加。本研究的目的是了解在一家三级医疗中心肾病科就诊的患者中微量白蛋白尿的患病率。 方法:这是一项描述性横断面研究,在获得机构审查委员会伦理批准(参考编号:04072022/04)后,对一家三级医疗中心肾病科就诊的糖尿病患者进行。研究于2022年10月1日至2022年11月30日进行,纳入提供书面同意且有糖尿病记录的患者,而无糖尿病记录、患有充血性心力衰竭、肾炎/肾病综合征等合并症以及拒绝给予同意的患者被排除在研究之外。采用方便抽样法。计算点估计值和95%置信区间。 结果:在103例患者中,发现19例(18.45%)存在微量白蛋白尿(10.96 - 25.94,95%置信区间)。在这19例患者中,8例(42.11%)为男性,11例(57.89%)为女性。微量白蛋白尿患者的平均糖化血红蛋白为7.67±0.67%。 结论:糖尿病患者中微量白蛋白尿的患病率与在类似环境中进行的其他研究相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3186/10395572/91529d46dc06/JNMA-61-263-596-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3186/10395572/91529d46dc06/JNMA-61-263-596-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3186/10395572/91529d46dc06/JNMA-61-263-596-g1.jpg

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本文引用的文献

[1]
Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications.

Eur J Prev Cardiol. 2019-11-13

[2]
Microalbuminuria and Its Risk Factors in Type 2 Diabetic Patients.

J Nepal Health Res Counc. 2019-4-28

[3]
Microalbuminuria, is it so important?

Hippokratia. 2007-7

[4]
Microalbuminuria among type-2 diabetes mellitus patients in Pokhara, Nepal.

Nepal Med Coll J. 2008-12

[5]
Systematic review on urine albumin testing for early detection of diabetic complications.

Health Technol Assess. 2005-8

[6]
An alarmingly high prevalence of diabetic nephropathy in Asian type 2 diabetic patients: the MicroAlbuminuria Prevalence (MAP) Study.

Diabetologia. 2005-1

[7]
Albumin turns on a vicious spiral of oxidative stress in renal proximal tubules.

Kidney Int. 2004-11

[8]
Microalbuminuria is associated with impaired brachial artery, flow-mediated vasodilation in elderly individuals without and with diabetes: further evidence for a link between microalbuminuria and endothelial dysfunction--the Hoorn Study.

Kidney Int Suppl. 2004-11

[9]
Progression of nephropathy in type 2 diabetic patients.

Kidney Int. 2004-10

[10]
Prevalence of microalbuminuria in type 2 diabetes mellitus at a diabetes centre in southern India.

Postgrad Med J. 2001-6

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