Xie Haixia, Zhang Qi, Jin Rong, He Jianhui, Hu Xinxing, Zhang Yixuan, Shao Xiaoping, Li Xiaohong, Zhai Hua, Chang Fengshui
Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
Joint School of Public Health, Macon & Joan Brock Virginia Health Sciences, Old Dominion University, Norfolk, VA, USA.
Value Health Reg Issues. 2025 Aug 11;50:101164. doi: 10.1016/j.vhri.2025.101164.
The EQ-5D is a brief measure for assessing health-related quality of life (HRQoL), but chronic spinal cord injury (CSCI) related psychometric evaluation of the EQ-5D-5L has not been explored. We conducted a validation study on the Chinese version of the EQ-5D-5L for individuals with CSCI in China.
A cross-sectional study was conducted in the Shanghai Sunshine Rehabilitation Center. The floor and ceiling effects, internal consistency, test and retest reliability, discriminatory power (only for EQ-5D-5L), convergent validity (using Spearman correlation coefficients), and known-group validity of the EQ-5D-5L and visual analog scale (VAS) were analyzed.
A total of 271 individuals with CSCI were included in analysis. The mean (SD) utility and VAS scores were 0.46 (0.31) and 66.8 (20.3), respectively, and they showed no floor or ceiling effects. The EQ-5D-5L demonstrated acceptable internal consistency (Cronbach's α = 0.84) and test-retest reliability. The average Shannon index (H') and Shannon Evenness index (J') of the EQ-5D-5L were 2.01 and 0.86, respectively. Satisfactory convergent validity was shown by the correlation analysis among the 5 EQ-5D-5L dimensions, EQ-5D-5L utility, EQ-VAS, the World Health Organization quality-of-life scale brief version, 7-item generalized anxiety disorder scale (GAD-7), 9-item patient health questionnaire (PHQ-9), and General Self-Efficacy Scale (GSES). Utility and VAS scores showed the predicted pattern among a priori known groups, with effect sizes ranging from 0.06 to 0.72 for the EQ-5D-5L, and 0.02 to 1.08 for the VAS.
The EQ-5D-5L is a reliable and valid measure of HRQoL for individuals with CSCI in China.
EQ-5D是一种用于评估健康相关生活质量（HRQoL）的简短工具，但尚未对与慢性脊髓损伤（CSCI）相关的EQ-5D-5L心理测量学评价进行探索。我们针对中国CSCI患者开展了EQ-5D-5L中文版的验证研究。
在上海阳光康复中心进行了一项横断面研究。分析了EQ-5D-5L的地板效应和天花板效应、内部一致性、重测信度、区分能力（仅针对EQ-5D-5L）、收敛效度（使用斯皮尔曼相关系数）以及已知组效度，同时分析了视觉模拟量表（VAS）。
共有271名CSCI患者纳入分析。效用值和VAS评分的均值（标准差）分别为0.46（0.31）和66.8（20.3），未显示地板效应或天花板效应。EQ-5D-5L显示出可接受的内部一致性（Cronbach's α = 0.84）和重测信度。EQ-5D-5L的平均香农指数（H'）和香农均匀度指数（J'）分别为2.01和0.86。EQ-5D-5L的5个维度、EQ-5D-5L效用值、EQ-VAS、世界卫生组织生活质量量表简表、7项广泛性焦虑障碍量表（GAD-7）、9项患者健康问卷（PHQ-9）和一般自我效能量表（GSES）之间的相关性分析显示出令人满意的收敛效度。效用值和VAS评分在先验已知组中呈现出预期模式，EQ-5D-5L的效应量范围为0.06至0.72，VAS的效应量范围为0.02至1.08。
EQ-5D-5L是评估中国CSCI患者HRQoL的一种可靠且有效的工具。
