Yazawa Y, Shea J J
ORL J Otorhinolaryngol Relat Spec. 1985;47(6):281-7. doi: 10.1159/000275786.
The morphological changes of the inner ear were observed after intravenous administration of 2 g/kg of urea to the guinea pigs with endolymphatic hydrops which had previously been produced by injecting 10% silver nitrate solution into the endolymphatic sac. They showed membranous collapse extensively in the saccule, moderately in the lower turns of the cochlea and less in the upper turns and the utricle. Because of these changes, it is reasonable to assume that urea is causing the endolymph to be reabsorbed in the endolymphatic duct. Furthermore, the effect of urea seemed to depend on the pathological condition of the duct which sometimes showed a varying degree of atrophied change after silver nitrate injection.
给预先通过向内淋巴囊注射10%硝酸银溶液造成内淋巴积水的豚鼠静脉注射2 g/kg尿素后，观察其内耳的形态学变化。结果显示，球囊广泛出现膜性塌陷，耳蜗下转中度塌陷，上转和椭圆囊塌陷程度较轻。基于这些变化，有理由推测尿素促使内淋巴在内淋巴管中被重吸收。此外，尿素的作用似乎取决于该导管的病理状况，该导管在注射硝酸银后有时会出现不同程度的萎缩性改变。
