Yazawa Y, Shea J J, Kitahara M
Arch Otolaryngol. 1985 May;111(5):301-4. doi: 10.1001/archotol.1985.00800070053006.
There have been several reports of perisaccular fibrosis of the endolymphatic sac in some autopsied cases of Meniere's disease. We attempted to initiate perisaccular fibrosis of the sac in guinea pigs by injecting a small amount of 10% silver nitrate solution that cauterizes the tissue readily to produce scar, ie, fibrosis. Ninety-nine guinea pigs out of 108 (92%) that were treated with silver nitrate showed the endolymphatic hydrops in varied extent, from slight to profound. The extent of hydrops might depend on the extent of destruction of the sac following the cauterization. The lumen of the sac was sometimes occupied with dense fibrous connective tissue with deposition of black-silver particles in it. The silver nitrate injection method is an easy way to produce endolymphatic hydrops in guinea pigs.
在梅尼埃病的一些尸检病例中，已有多篇关于内淋巴囊球囊周纤维化的报道。我们试图通过注射少量10%的硝酸银溶液来引发豚鼠内淋巴囊的球囊周纤维化，该溶液能迅速烧灼组织以产生瘢痕，即纤维化。108只接受硝酸银治疗的豚鼠中有99只（92%）出现了不同程度的内淋巴积水，从轻微到严重。积水的程度可能取决于烧灼后囊的破坏程度。囊腔有时被致密的纤维结缔组织占据，其中有黑色银颗粒沉积。硝酸银注射法是在豚鼠中产生内淋巴积水的一种简便方法。
