The Potential and Underlying Mechanisms of Punicalagin in Mitigating Enterotoxigenic Escherichia coli-Induced Diarrhea.

Punicalagin is a well-studied polyphenolic compound with a wide array of pharmacological effects. This review summarizes its potential mechanisms of action along with the pathogenic implications and molecular pathways associated with enterotoxigenic Escherichia coli (ETEC). One primary mechanism by which punicalagin exerts its effects is through antibacterial activity that suppresses ETEC proliferation and mitigates intestinal infections. It further promotes the growth of beneficial microbiota, including bifidobacteria and lactic acid-producing bacteria, thereby improving the symbiotic balance of the gut microbiome and bolstering resistance to ETEC colonization. In addition, punicalagin has been shown to inhibit the activity of ETEC, thereby enhancing intestinal mucosal integrity and fortifying the intestinal barrier. This action reduces the permeability of harmful substances, ultimately protecting gut health. Moreover, punicalagin has the potential to chelate metals, leading to various biological activities and applications. This positions it as a candidate for further exploration as a novel therapeutic agent or a raw material in health products. In conclusion, this study offers preliminary insights into the potential application of punicalagin in managing ETEC-induced diarrhea, highlighting its pharmacological efficacy. However, it should be emphasized that current clinical evidence supporting its effectiveness for this specific use remains limited and preliminary, requiring validation through rigorous clinical trials.