To evaluate the effects of "Internet+"-based continuous nursing interventions in patients with pediatric liver transplantation. Seventy-six patients admitted between April 2019 and January 2021 were randomly divided into two groups (n = 38) using a random number table. The control group received conventional continuous nursing, whereas the observation group received "Internet+"-based continuous nursing strategies in addition to conventional care. After 4 weeks, the observation group had a lower nutritional risk rate (21.06%) than the control group (42.11%). Scores on the Caregiver Stress Index (3.65 ± 1.29) and Self-Rating Depression Scale (38.25 ± 4.32) in the observation group were substantially lower than those in the control group (7.84 ± 1.35 and 52.68 ± 4.15, respectively). The levels of albumin, prealbumin, total protein, and hemoglobin in the observation group were higher. Full adherence rates were also higher in the observation group (94.74%) than in the control group (73.68%). Postoperative complication rates were lower in the observation group (5.26%) compared with the control group (21.06%). "Internet+"-based continuous nursing improves nutritional status, reduces caregiver stress and negative emotions, enhances family adherence, and lowers postoperative complication rates in patients with pediatric liver transplantation. This approach warrants further promotion and application.