Dai Zi-Qi, Kong Ming-Yue, Li Tian-Jiao, Wu Xu-Jin, Zhang Xue-Song, Li Rui, Chen Xin
Changchun University of Chinese Medicine, Changchun, 130000, China.
Department of Gynecology, Affiliated Hospital of Changchun University of Chinese Medicine, 1478 Gongnong Road, Chaoyang District, ChangchunJilin, 130000, No, China.
J Assist Reprod Genet. 2025 Aug 14. doi: 10.1007/s10815-025-03618-y.
BACKGROUND: Infertility has emerged as a significant public health concern with implications for population development. Despite its relevance, there has been limited research addressing the association between infertility and triglyceride-glucose (TyG) index-derived indicators. This study examined the relationship between infertility and three TyG-related composite indices: TyG-BMI (TyG index combined with body mass index), TyG-WC (TyG index combined with waist circumference), and TyG-WHtR (TyG index combined with waist-to-height ratio). METHODS: Data were obtained from the 2013-2020 National Health and Nutrition Examination Survey, including a representative sample of 2856 adult participants. TyG-related indices were calculated using fasting triglyceride and glucose concentrations in combination with anthropometric measurements. Associations between infertility and TyG, TyG-BMI, TyG-WC, and TyG-WHtR were assessed using weighted multivariate logistic regression, subgroup analyses, smooth curve fitting, and threshold effect modeling. RESULTS: Significant positive associations were observed between infertility and TyG-BMI (odds ratio (OR), 1.003; 95% confidence interval (CI), 1.001-1.004), TyG-WC (OR, 1.001; 95% CI, 1.000-1.002), and TyG-WHtR (OR, 1.186; 95% CI, 1.058-1.329). Subgroup analyses indicated consistent positive associations within specific populations. Among Mexican American participants, all TyG-related indicators were significantly associated with infertility. In married participants and non-Hispanic White participants, TyG-BMI, TyG-WC, and TyG-WHtR demonstrated significant associations with infertility. Two-stage linear regression analyses did not depict any evidence of nonlinear relationships between these indices and infertility. CONCLUSION: TyG-BMI, TyG-WC, and TyG-WHtR were identified as risk factors for infertility, with no observed nonlinear associations. These findings highlight the relevance of TyG-related metabolic indicators in reproductive health, warranting further investigation into their underlying pathophysiological mechanisms.
背景：不孕症已成为一个重大的公共卫生问题，对人口发展产生影响。尽管其具有相关性，但针对不孕症与甘油三酯-葡萄糖（TyG）指数衍生指标之间关联的研究有限。本研究探讨了不孕症与三个TyG相关复合指数之间的关系：TyG-BMI（TyG指数与体重指数相结合）、TyG-WC（TyG指数与腰围相结合）和TyG-WHtR（TyG指数与腰高比相结合）。 方法：数据来自2013 - 2020年国家健康与营养检查调查，包括2856名成年参与者的代表性样本。TyG相关指数通过结合空腹甘油三酯和葡萄糖浓度以及人体测量数据来计算。使用加权多元逻辑回归、亚组分析、平滑曲线拟合和阈值效应模型评估不孕症与TyG、TyG-BMI、TyG-WC和TyG-WHtR之间的关联。 结果：在不孕症与TyG-BMI（优势比（OR），1.003；95%置信区间（CI），1.001 - 1.004）、TyG-WC（OR，1.001；95% CI，1.000 - 1.002）和TyG-WHtR（OR，1.186；95% CI，1.058 - 1.329）之间观察到显著的正相关。亚组分析表明在特定人群中存在一致的正相关。在墨西哥裔美国参与者中，所有TyG相关指标均与不孕症显著相关。在已婚参与者和非西班牙裔白人参与者中，TyG-BMI、TyG-WC和TyG-WHtR与不孕症表现出显著关联。两阶段线性回归分析未显示这些指数与不孕症之间存在非线性关系的任何证据。 结论：TyG-BMI、TyG-WC和TyG-WHtR被确定为不孕症的危险因素，未观察到非线性关联。这些发现凸显了TyG相关代谢指标在生殖健康中的相关性，有必要进一步研究其潜在的病理生理机制。
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