不同胰岛素抵抗替代指标与育龄女性不孕之间的关联。
Association between different insulin resistance surrogates and infertility in reproductive-aged females.
作者信息
Xia Weiting, Cai Yaoyao, Zhang Sisi, Wu Shenghao
机构信息
Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Obstetrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
出版信息
BMC Public Health. 2023 Oct 12;23(1):1985. doi: 10.1186/s12889-023-16813-2.
BACKGROUND
Obesity and metabolic syndrome are observed more frequently in infertile women, and insulin resistance (IR) is closely related to them. However, there are no studies that have examined the association between different IR surrogates and female infertility, hence we investigated the potential association between them in the general population.
METHODS
This was a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES, 2013-2018). The association of different IR surrogates (HOMA-IR index, TyG index and TyG-BMI index) with female infertility was estimated by multivariable regression analysis.
RESULTS
After adjusting for confounders, the HOMA-IR index and TyG index did not show an association with female infertility, while the TyG-BMI index was found to have a positive association with female infertility (OR = 1.01, 95% CI: 1.00, 1.01; P < 0.0001), and the OR of the TyG-BMI group T3 (≥ 255.55) was significantly different compared to the group T1 (< 185.31) (OR = 3.02, 95% CI: 1.62, 5.60). Similar results were seen in most of the subgroup participants by stratified analysis (P-interaction > 0.05). However, different IR surrogates did not show variability in their ability to predict infertility [TyG-BMI: 0.68 (95% CI: 0.62, 0.74) vs. TyG: 0.62 (95% CI: 0.57, 0.68) vs. HOMA-IR: 0.65 (95% CI: 0.60, 0.71)].
CONCLUSIONS
Our result suggests that high levels of TyG-BMI index were positively associated with female infertility in US reproductive-aged females.
背景
肥胖和代谢综合征在不孕女性中更为常见，且胰岛素抵抗（IR）与它们密切相关。然而，尚无研究探讨不同IR替代指标与女性不孕之间的关联，因此我们在一般人群中调查了它们之间的潜在关联。
方法
这是一项横断面研究，使用了美国国家健康与营养检查调查（NHANES，2013 - 2018年）的数据。通过多变量回归分析评估不同IR替代指标（HOMA - IR指数、TyG指数和TyG - BMI指数）与女性不孕的关联。
结果
在调整混杂因素后，HOMA - IR指数和TyG指数与女性不孕无关联，而TyG - BMI指数与女性不孕呈正相关（OR = 1.01，95%CI：1.00，1.01；P < 0.0001），且TyG - BMI组T3（≥255.55）的OR与组T1（<185.31）相比有显著差异（OR = 3.02，95%CI：1.62，5.60）。分层分析在大多数亚组参与者中也观察到类似结果（P交互作用>0.05）。然而，不同IR替代指标在预测不孕的能力上没有差异[TyG - BMI：0.68（95%CI：0.62，0.74） vs. TyG：0.62（95%CI：0.57，0.68） vs. HOMA - IR：0.65（95%CI：0.60，0.71）]。
结论
我们的结果表明，在美国育龄女性中，高水平的TyG - BMI指数与女性不孕呈正相关。
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