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The complosome - a key regulator of hematopoietic stem cells and innate immune responses.

作者信息

Ulrich Henning

机构信息

Department of Biochemistry, Institute of Chemistry, University of São Paulo, São Paulo, Brazil.

出版信息

Leukemia. 2025 Sep;39(9):2297-2298. doi: 10.1038/s41375-025-02728-x. Epub 2025 Aug 13.

DOI:10.1038/s41375-025-02728-x
PMID:40804470
Abstract
摘要

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本文引用的文献

1
Complosome Regulates Hematopoiesis at the Mitochondria Level.复合小体在线粒体水平调节造血作用。
Stem Cell Rev Rep. 2025 May;21(4):1001-1012. doi: 10.1007/s12015-025-10856-1. Epub 2025 Mar 7.
2
The Different Responsiveness of C3- and C5-deficient Murine BM Cells to Oxidative Stress Explains Why C3 Deficiency, in Contrast to C5 Deficiency, Correlates with Better Pharmacological Mobilization and Engraftment of Hematopoietic Cells.C3缺陷和C5缺陷的小鼠骨髓细胞对氧化应激的不同反应性解释了为什么与C5缺陷相反，C3缺陷与造血细胞更好的药物动员和植入相关。
Stem Cell Rev Rep. 2025 Jan;21(1):59-67. doi: 10.1007/s12015-024-10792-6. Epub 2024 Sep 28.
3
Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner.
细胞内补体（补体小体）在造血干/祖细胞（HSPCs）中表达，并以内分泌样的Nlrp3炎性小体依赖性方式调节细胞运输、代谢和增殖。
Leukemia. 2023 Jun;37(6):1401-1405. doi: 10.1038/s41375-023-01894-0. Epub 2023 Apr 13.
4
Less Can Be More: The Hormesis Theory of Stress Adaptation in the Global Biosphere and Its Implications.少即是多：全球生物圈中应激适应的毒物兴奋效应理论及其启示
Biomedicines. 2021 Mar 13;9(3):293. doi: 10.3390/biomedicines9030293.
5
A novel "complement-metabolism-inflammasome axis" as a key regulator of immune cell effector function.一种新型的“补体代谢-炎性小体轴”作为免疫细胞效应功能的关键调节因子。
Eur J Immunol. 2016 Jul;46(7):1563-73. doi: 10.1002/eji.201546131. Epub 2016 Jun 8.
6
Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation.细胞内补体激活维持 T 细胞稳态并介导效应细胞分化。
Immunity. 2013 Dec 12;39(6):1143-57. doi: 10.1016/j.immuni.2013.10.018. Epub 2013 Dec 5.