Shin Chang Hoon, Kim Kyungmin, Ho Chul Woong, Lee Ji Won, Jo Min Jeong, Min Kyung-Won, Yoon Je-Hyun
Department of Oncology Science, University of Oklahoma, Oklahoma City, OK, USA.
Department of Biology, College of Natural Sciences, Gangneung-Wonju National University, Gangneung-si, Republic of Korea.
Exp Mol Med. 2025 Aug 14. doi: 10.1038/s12276-025-01464-7.
Long noncoding RNAs (lncRNAs) have emerged as critical regulators of cancer development and progression by modulating enzymatic reactions involved in cellular metabolism and protein modifications. These noncoding transcripts exert their roles through molecular interactions with target proteins. Here we explore the diverse mechanisms through which lncRNAs optimize enzymatic reactions in metabolic processes and protein modifications, both of which are fundamental to the growth, adaptation, and survival of cancer cells. These processes, often dysregulated during cancer progression, are modulated by lncRNAs through direct interactions with specific proteins, underscoring their critical role in oncogenesis. Key research findings are summarized to provide a comprehensive understanding of the roles of lncRNAs in modulating these cellular processes. This Review offers an in-depth overview of the complex regulatory networks through which lncRNAs influence cancer pathogenesis and provides essential insights for the development of future therapeutic strategies.
长链非编码RNA（lncRNAs）已成为癌症发生和发展的关键调节因子，通过调节参与细胞代谢和蛋白质修饰的酶促反应来发挥作用。这些非编码转录本通过与靶蛋白的分子相互作用发挥其功能。在此，我们探讨lncRNAs优化代谢过程和蛋白质修饰中酶促反应的多种机制，这两者对于癌细胞的生长、适应和存活至关重要。这些过程在癌症进展过程中常常失调，lncRNAs通过与特定蛋白质的直接相互作用对其进行调节，突出了它们在肿瘤发生中的关键作用。本文总结了关键研究发现，以全面了解lncRNAs在调节这些细胞过程中的作用。本综述深入概述了lncRNAs影响癌症发病机制的复杂调控网络，并为未来治疗策略的开发提供了重要见解。
