Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA; Department of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.
Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA; Department of Radiation Oncology, New York University Grossman School of Medicine, New York, NY, USA.
Trends Cancer. 2023 Jun;9(6):461-471. doi: 10.1016/j.trecan.2023.02.005. Epub 2023 Mar 17.
Cancer is a systemic disease that involves malignant cell-intrinsic and -extrinsic metabolic adaptations. Most studies have tended to focus on elucidating the metabolic vulnerabilities in the primary tumor microenvironment, leaving the metastatic microenvironment less explored. In this opinion article, we discuss the current understanding of the metabolic crosstalk between the cancer cells and the tumor microenvironment, both at local and systemic levels. We explore the possible influence of the primary tumor secretome to metabolically and epigenetically rewire the nonmalignant distant organs during prometastatic niche formation and successful metastatic colonization by the cancer cells. In an attempt to understand the process of prometastatic niche formation, we have speculated how cancer may hijack the inherent regenerative propensity of tissue parenchyma during metastatic colonization.
癌症是一种全身性疾病，涉及恶性细胞内在和外在的代谢适应。大多数研究倾向于阐明原发性肿瘤微环境中的代谢脆弱性，而对转移性微环境的研究较少。在这篇观点文章中，我们讨论了目前对癌细胞与肿瘤微环境之间代谢串扰的理解，包括局部和全身水平。我们探讨了原发性肿瘤分泌组在促进转移龛形成过程中以及癌细胞成功转移定植时对非恶性远处器官进行代谢和表观遗传重塑的可能影响。为了试图理解促进转移龛形成的过程，我们推测了癌症在转移定植过程中如何劫持组织实质固有的再生倾向。
