Gao Xiaowen, Li Shidan, Wu Jinze, Feng Yiyun, Xing Wei, Li Xiaoming, Du Yimin, Guo Debin, Xu Honghao, Tang Dongqin, Wang Shaochuan, Li Youbin, Yang Jing, Ma Jianfei, Zhang Yamei, Li Lei, Fei Jun
War Trauma Medical Center, Army Medical Center, Third Military Medical University, Chongqing, 400042, China.
Nanjing No.29 High School, Nanjing, 210019, China.
BMC Infect Dis. 2025 Aug 13;25(1):1015. doi: 10.1186/s12879-025-11282-x.
Sepsis is a life-threatening syndrome characterized by multiple organ dysfunction resulting from a maladjusted host response to infection. It remains a leading cause of morbidity and mortality worldwide. Early intervention for sepsis improves clinical outcomes. This study aimed to develop a diagnostic and prognostic indicator at the onset of sepsis.
From January 2021 to December 2023, patients in the emergency department (ED) were evaluated for the use of Fibulin2 as a diagnostic and prognostic indicator for sepsis. The levels of Fibulin2 in plasma were detected via enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristic (ROC) curves were generated to assess the performance of Fibulin2 for predicting sepsis.
The level of serum Fibulin2 was significantly higher in patients with sepsis than in controls, and Fibulin2 had diagnostic value for sepsis and performed better than C-reactive protein (CRP), procalcitonin (PCT), the white blood cell count (WBC), the neutrophil ratio (NEU%), and D-dimer. Overall, Fibulin2 was upregulated in patients with septic shock compared with septic patients without shock, and Fibulin2 can be used to diagnose septic shock. Moreover, Fibulin2 was increased in patients who died at 28 days of sepsis and had the potential to predict 28-day mortality.
Fibulin2 may serve as a diagnostic and prognostic biomarker for sepsis in the ED.
脓毒症是一种危及生命的综合征，其特征是宿主对感染的反应失调导致多器官功能障碍。它仍然是全球发病和死亡的主要原因。脓毒症的早期干预可改善临床结局。本研究旨在开发一种脓毒症发病时的诊断和预后指标。
2021年1月至2023年12月，对急诊科患者评估纤维蛋白2作为脓毒症诊断和预后指标的应用。通过酶联免疫吸附测定（ELISA）检测血浆中纤维蛋白2的水平。生成受试者工作特征（ROC）曲线以评估纤维蛋白2预测脓毒症的性能。
脓毒症患者血清纤维蛋白2水平显著高于对照组，纤维蛋白2对脓毒症具有诊断价值，且表现优于C反应蛋白（CRP）、降钙素原（PCT）、白细胞计数（WBC）、中性粒细胞比例（NEU%）和D-二聚体。总体而言，与无休克的脓毒症患者相比，感染性休克患者的纤维蛋白2上调，且纤维蛋白2可用于诊断感染性休克。此外，脓毒症28天死亡患者的纤维蛋白2升高，且有可能预测28天死亡率。
纤维蛋白2可能作为急诊科脓毒症的诊断和预后生物标志物。
