Chen Vera Y, Fullarton Rachel, Chen Yu
Department of Laboratory Medicine, Dr. Everett Chalmers Regional Hospital, Horizon Health Network, Fredericton, NB E3B 5N5, Canada.
Faculty of Science, University of New Brunswick, Fredericton, NB E3B 5A3, Canada.
Diagnostics (Basel). 2025 Jul 31;15(15):1923. doi: 10.3390/diagnostics15151923.
: Core laboratory chemistry analyzers typically use plasma and serum samples, while blood gas instruments use whole blood for electrolyte and metabolite tests. Due to high costs to back up the core lab chemistry analyzers, especially in the remote small community hospitals, we have verified the interchangeability of serum/plasma electrolytes and metabolites on blood gas instruments (GEM4000 and Radiometer ABL90) vs. chemistry analyzers. In this study, we sought to extend the investigation to another blood gas device-Radiometer ABL837. : One plasma separator tube and one serum separator tube were drawn from 20 apparently healthy individuals and outpatients and 20 intensive care unit patients. All the samples were run on Roche Cobas8000, and then were run on three Radiometer ABL837 analyzers for sodium (Na), potassium (K), chloride (Cl), glucose, lactate (plasma only), and creatinine parameters. Paired measurements between the ABL837 and Cobas8000 were compared, and their difference were assessed for statistical and clinical significance. : ABL837 demonstrated statistical significance ( < 0.05) vs. Cobas8000 on all the plasma and serum parameters. However, no parameter differences were found when comparing the plasma/serum results on ABL837 to those on Cobas8000, indicating that none were clinically significant. ABL837 also demonstrated good-excellent correlations with Cobas8000 on all the parameters. : When comparing metabolite and electrolyte values with plasma and serum sample types, the ABL837 blood gas instruments and Cobas 8000 chemistry analyzer are interchangeable. These data proves that ABL837 can be used as a backup for a chemistry analyzer in measuring plasma and serum electrolyte and metabolite concentrations.
核心实验室化学分析仪通常使用血浆和血清样本，而血气分析仪则使用全血进行电解质和代谢物检测。由于备份核心实验室化学分析仪成本高昂，尤其是在偏远的小型社区医院，我们已经验证了血气分析仪（GEM4000和Radiometer ABL90）与化学分析仪相比，血清/血浆电解质和代谢物的互换性。在本研究中，我们试图将调查扩展到另一台血气设备——Radiometer ABL837。
从20名看似健康的个体、门诊患者和20名重症监护病房患者中采集了一支血浆分离管和一支血清分离管。所有样本先在罗氏Cobas8000上进行检测，然后在三台Radiometer ABL837分析仪上检测钠（Na）、钾（K）、氯（Cl）、葡萄糖、乳酸（仅血浆）和肌酐参数。比较了ABL837和Cobas8000之间的配对测量值，并评估了它们之间差异的统计学和临床意义。
ABL837在所有血浆和血清参数上与Cobas8000相比均具有统计学意义（<0.05）。然而，将ABL837上的血浆/血清结果与Cobas8000上的结果进行比较时，未发现参数差异，这表明没有一个差异具有临床意义。ABL837在所有参数上与Cobas8000也表现出良好至极好的相关性。
在比较代谢物和电解质值与血浆和血清样本类型时，ABL837血气分析仪和Cobas 8000化学分析仪是可互换的。这些数据证明，ABL837可作为化学分析仪的备用设备，用于测量血浆和血清电解质及代谢物浓度。
