Betea Razvan, Budisan Camelia, Stanga Livia, Muresan Maria Cezara, Popa Zoran Laurentiu, Citu Cosmin, Ratiu Adrian, Chiriac Veronica Daniela
Doctoral School, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Department of Obstetrics and Gynecology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Healthcare (Basel). 2025 Jul 23;13(15):1787. doi: 10.3390/healthcare13151787.
: Uterine cancer is the most common gynaecologic malignancy in developed countries, yet the psychosocial sequelae of treatment are incompletely described. This prospective, single-centre study quantified six-month changes in the quality of life (QoL) and perceived stress in women with newly diagnosed uterine cancer and explored clinical moderators of change. : Participants completed four validated self-report questionnaires: the 36-item Short-Form Health Survey (SF-36), the 26-item World Health Organization Quality-of-Life-BREF (WHOQOL-BREF), the 30-item EORTC QLQ-C30 and the 10-item Perceived Stress Scale (PSS-10) before therapy and again six months after surgery ± adjuvant chemoradiation. Subgroup analyses were performed for stage (FIGO I-II vs. III-IV). : Mean SF-36 Physical Functioning improved from 58.7 ± 12.1 to 63.1 ± 12.6 (Δ = +4.4 ± 7.3; = 0.000, = 0.36). PSS declined from 24.1 ± 5.6 to 20.8 ± 5.4 (Δ = -3.3 ± 5.0; < 0.001, = 0.66). The WHOQOL-BREF Physical and Psychological domains rose by 4.4 ± 6.9 and 3.5 ± 7.3 points, respectively (both < 0.01). EORTC QLQ-C30 Global Health increased 5.1 ± 7.6 points ( < 0.001) with parallel reductions in fatigue (-5.4 ± 9.0) and pain (-4.8 ± 8.6). Advanced-stage patients showed larger reductions in stress (ΔPSS -3.5 ± 2.5 vs. -2.3 ± 2.3; = 0.036) but similar QoL gains. ΔPSS correlated inversely with ΔWHOQOL Psychological (r = -0.53) and ΔSF-36 Mental Health (r = -0.49) and positively with ΔEORTC Global Health (r = -0.42) (all < 0.001). : Over six months, multimodal uterine cancer treatment was associated with clinically meaningful QoL improvements and moderate stress reduction. Greater stress relief paralleled superior gains in psychological and global health indices, highlighting the importance of integrative survivorship care.
子宫癌是发达国家最常见的妇科恶性肿瘤，然而治疗的心理社会后遗症尚未得到充分描述。这项前瞻性单中心研究量化了新诊断子宫癌女性患者生活质量（QoL）和感知压力在六个月内的变化，并探讨了变化的临床调节因素。参与者在治疗前和手术±辅助放化疗六个月后分别完成了四份经过验证的自我报告问卷：36项简短健康调查问卷（SF-36）、26项世界卫生组织生活质量简表（WHOQOL-BREF）、30项欧洲癌症研究与治疗组织核心问卷（EORTC QLQ-C30）以及10项感知压力量表（PSS-10）。对分期（国际妇产科联盟（FIGO）I-II期与III-IV期）进行了亚组分析。SF-36身体功能平均得分从58.7±12.1提高到63.1±12.6（Δ=+4.4±7.3；P=0.000，效应量=0.36）。PSS得分从24.1±5.6降至20.8±5.4（Δ=-3.3±5.0；P<0.001，效应量=0.66）。WHOQOL-BREF的身体和心理领域分别提高了4.4±6.9分和3.5±7.3分（均P<0.01）。EORTC QLQ-C30全球健康状况提高了5.1±7.6分（P<0.001），同时疲劳（-5.4±9.0）和疼痛（-4.8±8.6）得分相应降低。晚期患者的压力降低幅度更大（ΔPSS -3.5±2.5 vs. -2.3±2.3；P=0.036），但生活质量改善情况相似。ΔPSS与ΔWHOQOL心理得分（r=-
