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肥胖儿童外周血单个核细胞中、、、及生脂基因的表达改变及其与添加糖摄入的关联

Altered Expression of the , , , and Lipogenic Genes in PBMCs from Children with Obesity and Its Associations with Added Sugar Intake.

作者信息

Hernández-DíazCouder Adrián, Paz-González Pablo J, Valdez-Garcia Maryori, Ramírez-Silva Claudia I, Avila-Soto Karol Iliana, Pérez-Bautista Araceli, Vazquez-Moreno Miguel, Nava-Cabrera Ana, Romero-Nava Rodrigo, Huang Fengyang, Cruz Miguel

机构信息

Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.

Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico.

出版信息

Nutrients. 2025 Aug 2;17(15):2546. doi: 10.3390/nu17152546.

DOI:10.3390/nu17152546
PMID:40806129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12348735/
Abstract

BACKGROUND

Obesity and its complications have increased in both adults and children, with pediatric populations developing metabolic disorders at earlier ages. Long non-coding RNAs, particularly , are involved in obesity through regulation of lipogenic genes including , , , , and . However, data on expression in pediatric obesity are limited. This study evaluated , , and expression in PBMCs from children with obesity and their associations with added sugar intake and lipid metabolism genes.

METHODS

In this cross-sectional study 71 children within the age range of 6 to 12 years were included (28 normal weight and 43 with obesity). Anthropometrical and clinical parameters and dietary added sugar consumption were analyzed. Real-time PCR was performed to assess , , , , , and gene expression in peripheral blood mononuclear cells.

RESULTS

The expression of , , , , , and was decreased in children with obesity. and showed sex-dependent expression in children without obesity, while additional sex-related differences were observed for , , , , and in children with obesity. was associated with the expression of , , , , and . In insulin-resistant (IR) children, , , , , and were reduced, while was increased. Added sugar intake negatively correlated with , , and .

CONCLUSIONS

The , , and expression was altered in children with obesity, showing sex- and IR-related differences. Added sugar intake correlated negatively with lipogenic gene expression.

摘要

背景

肥胖及其并发症在成人和儿童中均有所增加，儿童群体在更早的年龄就出现代谢紊乱。长链非编码RNA，尤其是[具体名称未给出]，通过调控包括[具体基因名称未给出]、[具体基因名称未给出]、[具体基因名称未给出]、[具体基因名称未给出]和[具体基因名称未给出]等脂肪生成基因参与肥胖过程。然而，关于[具体名称未给出]在儿童肥胖中表达的数据有限。本研究评估了肥胖儿童外周血单核细胞（PBMCs）中[具体名称未给出]、[具体名称未给出]和[具体名称未给出]的表达及其与添加糖摄入和脂质代谢基因的关联。

方法

在这项横断面研究中，纳入了71名6至12岁的儿童（28名体重正常，43名肥胖）。分析了人体测量和临床参数以及饮食中添加糖的摄入量。采用实时聚合酶链反应（PCR）评估外周血单核细胞中[具体名称未给出]、[具体名称未给出]、[具体名称未给出]、[具体名称未给出]、[具体名称未给出]和[具体基因名称未给出]的基因表达。

结果

肥胖儿童中[具体名称未给出]、[具体名称未给出]、[具体名称未给出]、[具体名称未给出]、[具体名称未给出]和[具体名称未给出]的表达降低。在体重正常的儿童中，[具体名称未给出]和[具体名称未给出]表现出性别依赖性表达，而在肥胖儿童中，观察到[具体名称未给出]、[具体名称未给出]、[具体名称未给出]、[具体名称未给出]和[具体名称未给出]存在其他与性别相关的差异。[具体名称未给出]与[具体名称未给出]、[具体名称未给出]、[具体名称未给出]、[具体名称未给出]和[具体名称未给出]的表达相关。在胰岛素抵抗（IR）儿童中，[具体名称未给出]、[具体名称未给出]、[具体名称未给出]、[具体名称未给出]和[具体名称未给出]降低，而[具体名称未给出]增加。添加糖摄入与[具体名称未给出]、[具体名称未给出]和[具体名称未给出]呈负相关。

结论

肥胖儿童中[具体名称未给出]、[具体名称未给出]和[具体名称未给出]的表达发生改变，呈现出与性别和胰岛素抵抗相关的差异。添加糖摄入与脂肪生成基因表达呈负相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c3e/12348735/41af5f519840/nutrients-17-02546-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c3e/12348735/b18ab24f5473/nutrients-17-02546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c3e/12348735/14f6ab0dd87a/nutrients-17-02546-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c3e/12348735/41af5f519840/nutrients-17-02546-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c3e/12348735/b18ab24f5473/nutrients-17-02546-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c3e/12348735/14f6ab0dd87a/nutrients-17-02546-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c3e/12348735/41af5f519840/nutrients-17-02546-g003.jpg

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本文引用的文献

1
Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021.1990年至2021年全球、区域和国家儿童及青少年超重和肥胖患病率及到2050年的预测：全球疾病负担研究2021的一项预测研究
Lancet. 2025 Mar 8;405(10481):785-812. doi: 10.1016/S0140-6736(25)00397-6. Epub 2025 Mar 3.
2
Atf4 Protects Islet β-Cell Identity and Function Under Acute Glucose-Induced Stress but Promotes β-Cell Failure in the Presence of Free Fatty Acid.激活转录因子4（Atf4）在急性葡萄糖诱导的应激下保护胰岛β细胞身份和功能，但在游离脂肪酸存在的情况下会促进β细胞功能衰竭。
Diabetes. 2025 May 1;74(5):838-849. doi: 10.2337/db24-0360.
3
LncRNA MEG3 Restrains Hepatic Lipogenesis via the FOXO1 Signaling Pathway in HepG2 Cells.
长链非编码 RNA MEG3 通过 FOXO1 信号通路抑制 HepG2 细胞的肝脂生成。
Cell Biochem Biophys. 2024 Jun;82(2):1253-1259. doi: 10.1007/s12013-024-01278-w. Epub 2024 May 7.
4
Fat mass and obesity-associated (FTO) gene is essential for insulin secretion and β-cell function: In vitro studies using INS-1 cells and human pancreatic islets.脂肪量和肥胖相关（FTO）基因对于胰岛素分泌和β细胞功能至关重要：使用 INS-1 细胞和人胰腺胰岛的体外研究。
Life Sci. 2024 Feb 15;339:122421. doi: 10.1016/j.lfs.2024.122421. Epub 2024 Jan 15.
5
Added sugar intake is associated with weight gain and risk of developing obesity over 30 years: The CARDIA study.添加糖的摄入量与体重增加和 30 多年来肥胖风险相关：CARDIA 研究。
Nutr Metab Cardiovasc Dis. 2024 Feb;34(2):466-474. doi: 10.1016/j.numecd.2023.10.022. Epub 2023 Oct 24.
6
[Not Available].[无可用内容]。
Salud Publica Mex. 2023 Jun 14;65:s218-s224. doi: 10.21149/14762.
7
LncRNA MEG3: Targeting the Molecular Mechanisms and Pathogenic causes of Metabolic Diseases.长链非编码 RNA MEG3：代谢性疾病的分子机制和发病原因的靶向治疗。
Curr Med Chem. 2024;31(37):6140-6153. doi: 10.2174/0109298673268051231009075027.
8
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Mol Neurobiol. 2024 Feb;61(2):1023-1043. doi: 10.1007/s12035-023-03622-2. Epub 2023 Sep 7.
9
LncRNA MEG3 aggravates adipocyte inflammation and insulin resistance by targeting IGF2BP2 to activate TLR4/NF-κB signaling pathway.长链非编码 RNA MEG3 通过靶向 IGF2BP2 激活 TLR4/NF-κB 信号通路加重脂肪细胞炎症和胰岛素抵抗。
Int Immunopharmacol. 2023 Aug;121:110467. doi: 10.1016/j.intimp.2023.110467. Epub 2023 Jun 20.
10
Decoding the regulatory roles of non-coding RNAs in cellular metabolism and disease.解析非编码 RNA 在细胞代谢和疾病中的调控作用。
Mol Ther. 2023 Jun 7;31(6):1562-1576. doi: 10.1016/j.ymthe.2023.04.012. Epub 2023 Apr 27.