Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, 443002, China.
College of Medicine and Health Science, China Three Gorges University, Yichang, 443002, China.
Curr Med Chem. 2024;31(37):6140-6153. doi: 10.2174/0109298673268051231009075027.
Non-coding RNA is a type of RNA that does not encode proteins, distributed among rRNA, tRNA, snRNA, snoRNA, microRNA and other RNAs with identified functions, where the Long non-coding RNA (lncRNA) displays a nucleotide length over 200. LncRNAs enable multiple biological processes in the human body, including cancer cell invasion and metastasis, apoptosis, cell autophagy, inflammation, etc. Recently, a growing body of studies has demonstrated the association of lncRNAs with obesity and obesity-induced insulin resistance and NAFLD, where MEG3 is related to glucose metabolism, such as insulin resistance. In addition, MEG3 has been demonstrated in the pathological processes of various cancers, such as mediating inflammation, cardiovascular disease, liver disease and other metabolic diseases.
To explore the regulatory role of lncRNA MEG3 in metabolic diseases. It provides new ideas for clinical treatment or experimental research.
In this paper, in order to obtain enough data, we integrate and analyze the data in the PubMed database.
LncRNA MEG3 can regulate many metabolic diseases, such as insulin resistance, NAFLD, inflammation and so on.
LncRNA MEG3 has a regulatory role in a variety of metabolic diseases, which are currently difficult to be completely cured, and MEG3 is a potential target for the treatment of these diseases. Here, we review the role of lncRNA MEG3 in mechanisms of action and biological functions in human metabolic diseases.
非编码 RNA 是一种不编码蛋白质的 RNA，分布在 rRNA、tRNA、snRNA、snoRNA、microRNA 等具有确定功能的 RNA 中，其中长链非编码 RNA（lncRNA）的核苷酸长度超过 200。lncRNAs 使人体的多种生物过程成为可能，包括癌细胞的侵袭和转移、细胞凋亡、细胞自噬、炎症等。最近，越来越多的研究表明 lncRNAs 与肥胖以及肥胖引起的胰岛素抵抗和非酒精性脂肪性肝病（NAFLD）有关，其中 MEG3 与葡萄糖代谢有关，如胰岛素抵抗。此外，MEG3 已在多种癌症的病理过程中得到证实，如介导炎症、心血管疾病、肝脏疾病和其他代谢疾病。
探讨 lncRNA MEG3 在代谢性疾病中的调控作用。为临床治疗或实验研究提供新的思路。
本文为了获得足够的数据，整合分析了 PubMed 数据库中的数据。
lncRNA MEG3 可以调节多种代谢性疾病，如胰岛素抵抗、NAFLD、炎症等。
lncRNA MEG3 在多种代谢性疾病中具有调节作用，这些疾病目前难以完全治愈，而 MEG3 是治疗这些疾病的潜在靶点。在这里，我们综述了 lncRNA MEG3 在人类代谢性疾病中的作用机制和生物学功能。
