Coşgun Süleyman, Ünal Derya, Çalışkan Kartal Aysun, Bedir Osman
Internal Medicine, Gastroenterology, Kütahya University of Health Sciences, Kütahya, TUR.
Internal Medicine, Kütahya University of Health Sciences, Kütahya, TUR.
Cureus. 2024 Sep 25;16(9):e70217. doi: 10.7759/cureus.70217. eCollection 2024 Sep.
Hepatosteatosis, which we frequently observe today with change in lifestyle, is often unnoticed, but preventable and reversible; if not prevented, it can lead to serious comorbidities. There is contradicting evidence in the literature; we believe that breastfeeding has a protective effect on hepatosteatosis. In this cross-sectional study we conducted, we aimed to examine the relationship between breastfeeding duration, metabolic parameters and fatty liver.
We examined the data of 135 patients aged 20-40 years who have had at least one pregnancy and were admitted to our polyclinic. Forty-five healthcare staff who never breastfed were included in the control group. Measurements of height and weight were taken, and number of children and total breastfeeding time were questioned. Blood values were measured to calculate insulin resistance, non-alcoholic fatty liver disease (NAFLD) fibrosis score and Fibrosis-4 (FIB-4) score.
Consequently, there was no significant correlation between total breastfeeding time and body mass index (BMI), NAFLD fibrosis score, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) value and hemoglobin A1C (HbA1C). When two groups were formed as patients breastfeeding for less than six months and patients breastfeeding for more than six months, a significant difference in BMI was observed between these two groups (p: 0.02). There was a significant relationship between BMI and NAFLD (p: 0.00) and HOMA-IR (p: 0.00). It was observed that there was a significant difference between BMI FIB-4 and NAFLD fibrosis scores of the control group and breastfed group.
Lactation should be maintained for at least six months for maternal health together with the baby's health, and more comprehensive studies should be conducted for long-term data.
肝脂肪变性在当今因生活方式改变而频繁出现，常常未被察觉，但可预防且可逆；若不加以预防，可能导致严重的合并症。文献中有相互矛盾的证据；我们认为母乳喂养对肝脂肪变性有保护作用。在我们进行的这项横断面研究中，我们旨在研究母乳喂养持续时间、代谢参数与脂肪肝之间的关系。
我们检查了135名年龄在20至40岁之间、至少有过一次怀孕经历且前来我们门诊就诊的患者的数据。45名从未进行过母乳喂养的医护人员被纳入对照组。测量了身高和体重，并询问了子女数量和总母乳喂养时间。测量血液值以计算胰岛素抵抗、非酒精性脂肪性肝病（NAFLD）纤维化评分和纤维化-4（FIB-4）评分。
结果显示，总母乳喂养时间与体重指数（BMI）、NAFLD纤维化评分、胰岛素抵抗稳态模型评估（HOMA-IR）值和糖化血红蛋白（HbA1C）之间无显著相关性。当将两组分为母乳喂养少于六个月的患者和母乳喂养超过六个月的患者时，观察到这两组之间的BMI存在显著差异（p：0.02）。BMI与NAFLD（p：0.00）和HOMA-IR（p：0.00）之间存在显著关系。观察到对照组和母乳喂养组的BMI、FIB-4和NAFLD纤维化评分之间存在显著差异。
为了母亲和婴儿的健康，母乳喂养应至少持续六个月，并且应该进行更全面的研究以获取长期数据。
