Bahadur A, Sodhi A
Pol J Pharmacol Pharm. 1985 Jul-Aug;37(4):453-61.
Effect of cis-dichlorodiammine platinum II (cis-platin) on Dalton's lymphoma in syngeneic (DBA) and allogeneic (Swiss white mice) system has been analyzed. Cytotoxic spleen cells from normal and tumor bearing mice (already treated with cis-platin at its full fledged state) were mixed in different ratios with the tumor cells (the same number of cells) to induce immunization in healthy mice. Capillary cell migration inhibition assay was also performed to study the development of immunity after chemotherapy. The immunization of mice with the platinum complex results in specific enhancement of the host cellular immune system.
已分析了顺二氯二氨铂（顺铂）对同基因（DBA）和异基因（瑞士小白鼠）系统中达尔顿淋巴瘤的作用。将来自正常小鼠和荷瘤小鼠（已用完全状态的顺铂处理过）的细胞毒性脾细胞与肿瘤细胞（相同数量的细胞）按不同比例混合，以在健康小鼠中诱导免疫。还进行了毛细血管细胞迁移抑制试验，以研究化疗后免疫的发展情况。用铂配合物对小鼠进行免疫可导致宿主细胞免疫系统的特异性增强。
