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生理衰老和过早衰老蜜蜂中三羧酸循环及呼吸链的效率（）

The Efficiency of the Krebs Cycle and the Respiratory Chain in Physiologically and Prematurely Aging Bees ().

作者信息

Kunat-Budzyńska Magdalena, Staniszewska Patrycja, Olszewski Krzysztof, Cytryńska Małgorzata, Strachecka Aneta

机构信息

Department of Immunobiology, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, Poland.

Department of Invertebrate Ecophysiology and Experimental Biology, University of Life Sciences in Lublin, 20-950 Lublin, Poland.

出版信息

Int J Mol Sci. 2025 Jul 28;26(15):7294. doi: 10.3390/ijms26157294.

DOI:10.3390/ijms26157294
PMID:40806426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12346989/
Abstract

The process of aging in organisms is associated with progressive metabolic changes that affect energy production. In our study, we compared the activities/concentrations of components related to the Krebs cycle and the respiratory chain (such as acetyl-CoA, IDH, AKG, succinate, fumarate, NADH, UQCR, COX and ATP) in the hemolymph and fat body segments (tergites 3 and 5, sternite) in naturally and prematurely (affected by ) aging workers. Tergite 3 showed the highest metabolic activity, indicating its key role in energy storage and production. In naturally aging workers, the concentrations/activities of the tested components were higher in all the segments of the fat body and all the age groups when compared to the prematurely aging workers. The concentrations/activities of these components increased with age, usually reaching the maximum at 28 days of age in the fat body segments of naturally aging workers, and then decreasing in the oldest ones (at 35 days of age). An analysis of changes in the metabolic processes can provide a lot of important information on the mechanisms of aging. In the future, such studies can contribute to the development of effective strategies to delay the aging processes and improve the overall condition of bee colonies.

摘要

生物体的衰老过程与影响能量产生的渐进性代谢变化相关。在我们的研究中，我们比较了自然衰老和早衰（受 影响）工蜂的血淋巴和脂肪体节段（背板 3 和 5、腹板）中与三羧酸循环和呼吸链相关的成分（如乙酰辅酶 A、异柠檬酸脱氢酶、α-酮戊二酸、琥珀酸、延胡索酸、烟酰胺腺嘌呤二核苷酸、泛醌细胞色素 c 还原酶、细胞色素 c 氧化酶和三磷酸腺苷）的活性/浓度。背板 3 显示出最高的代谢活性，表明其在能量储存和产生中的关键作用。与早衰工蜂相比，在自然衰老工蜂中，脂肪体所有节段以及所有年龄组中测试成分的浓度/活性更高。这些成分的浓度/活性随年龄增加，通常在自然衰老工蜂的脂肪体节段中在 28 日龄时达到最高，然后在最老的工蜂（35 日龄）中下降。对代谢过程变化的分析可以提供许多关于衰老机制的重要信息。未来，此类研究可为制定延缓衰老过程和改善蜂群整体状况的有效策略做出贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/45bb5ae2e7d8/ijms-26-07294-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/4fc0c37437a7/ijms-26-07294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/05ad549ca690/ijms-26-07294-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/85aa67dd878e/ijms-26-07294-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/230532f08bf8/ijms-26-07294-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/1f4345d0cd33/ijms-26-07294-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/13fdd2d1ae03/ijms-26-07294-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/3d577bc72512/ijms-26-07294-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/908dea62ce57/ijms-26-07294-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/45bb5ae2e7d8/ijms-26-07294-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/4fc0c37437a7/ijms-26-07294-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/05ad549ca690/ijms-26-07294-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/85aa67dd878e/ijms-26-07294-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/230532f08bf8/ijms-26-07294-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/1f4345d0cd33/ijms-26-07294-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/13fdd2d1ae03/ijms-26-07294-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/3d577bc72512/ijms-26-07294-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/908dea62ce57/ijms-26-07294-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8e/12346989/45bb5ae2e7d8/ijms-26-07294-g009.jpg

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本文引用的文献

[1]
Imidacloprid decreases energy production in the hemolymph and fat body of western honeybees even though, in sublethal doses, it increased the values of six of the nine compounds in the respiratory and citric cycle.

PLoS One. 2025-7-1

[2]
Insecticide and pathogens co-exposure induces histomorphology changes in midgut and energy metabolism disorders on Apis mellifera.

Pestic Biochem Physiol. 2025-6

[3]
Antioxidant Activities in the Hemolymph and Fat Body of Physiologically and Prematurely Aging Bees ().

Antioxidants (Basel). 2025-3-21

[4]
Changes in the Activities of Antioxidant Enzymes in the Fat Body and Hemolymph of L. Due to Pollen Monodiets.

Antioxidants (Basel). 2025-1-9

[5]
Interactive effects of chlorothalonil and Varroa destructor on Apis mellifera during adult stage.

Pestic Biochem Physiol. 2024-9

[6]
The effect of pollen monodiets on fat body morphology parameters and energy substrate levels in the fat body and hemolymph of Apis mellifera L. workers.

Sci Rep. 2024-7-2

[7]
Metabolism gene expression in worker honey bees after exposure to 50Hz electric field - semi-field analysis.

Front Zool. 2024-5-29

[8]
Tricarboxylic Acid Cycle Intermediates and Individual Ageing.

Biomolecules. 2024-2-22

[9]
Correlation Between Increased Homing Flight Duration and Altered Gene Expression in the Brain of Honey Bee Foragers After Acute Oral Exposure to Thiacloprid and Thiamethoxam.

Front Insect Sci. 2021-12-10

[10]
Age-related flexibility of energetic metabolism in the honey bee Apis mellifera.

FASEB J. 2023-11

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