Constantinescu Alexandra Elena, Mărunțelu Ion, Pleșa Andreea, Sîrbu Carmen Adella, Pleșa Florentina Cristina, Constantinescu Andreia Ioana, Constantinescu Ileana
Faculty of Medicine, "Carol Davila" Medical University Bucharest, 020021 Bucharest, Romania.
"Emil Palade" Center of Excellence for Young People in Scientific Research (EP-CEYR), Academy of Romanian Scientists, 030167 Bucharest, Romania.
Int J Mol Sci. 2025 Aug 6;26(15):7628. doi: 10.3390/ijms26157628.
Multiple sclerosis (MS) is a chronic autoimmune disease characterized by the immune system attacking the central nervous system, leading to demyelination and neurodegeneration. This work investigates the relationship between specific human leukocyte antigen (HLA) polymorphisms and MS, aiming to reveal the immunogenetic background of this disease for more individualized management approaches. This study employed a case-control design, analyzing HLA allele frequencies in 179 MS patients and 200 control subjects using next-generation sequencing, The key findings indicate significant associations between several HLA Class I and II alleles and MS, including HLA-B35:03:01:03, HLA-C04:01:01:14, HLA-DRB115:01:01:26, and HLA-DQA105:05:01:02. These findings emphasize the critical role of HLA molecules in MS Romanian patients.
多发性硬化症（MS）是一种慢性自身免疫性疾病，其特征是免疫系统攻击中枢神经系统，导致脱髓鞘和神经退行性变。这项工作研究了特定人类白细胞抗原（HLA）多态性与MS之间的关系，旨在揭示这种疾病的免疫遗传背景，以实现更个性化的管理方法。本研究采用病例对照设计，使用下一代测序分析了179例MS患者和200例对照受试者的HLA等位基因频率。关键发现表明，几种HLA I类和II类等位基因与MS之间存在显著关联，包括HLA-B35:03:01:03、HLA-C04:01:01:14、HLA-DRB115:01:01:26和HLA-DQA105:05:01:02。这些发现强调了HLA分子在罗马尼亚MS患者中的关键作用。
