: This study aimed to evaluate the effects of AMCOP elastodontic appliances on cephalometric parameters of skeletal divergence and upper airway dimensions in growing patients, comparing treated individuals with an untreated control group. : A total of 60 subjects (30 treated with AMCOP devices and 30 controls) were selected, with mean ages of 8.67 ± 1.3 and 9.19 ± 0.8 years, respectively. The AMCOP appliances, designed for mixed dentition, were worn for 1 h during the day and throughout the night for 6-8 months. Cephalometric analyses were conducted at the beginning (T0) and end (T1) of treatment. Statistical analyses were performed using multivariable linear regression models to assess changes in skeletal and airway parameters, with significance set at < 0.05. : Significant reductions were observed in Ans-Snp^Go-Gn ( = 0.0351), SN^Go-Gn ( = 0.0091), and FMA ( < 0.001) in the treated group compared to controls, indicating improved mandibular rotation. Upper airway spaces (SPAS, MAS, IAS) increased significantly, suggesting enhanced airway patency. Regression models confirmed the positive impact of AMCOP therapy on skeletal and airway outcomes, particularly in subjects with pronounced vertical discrepancies. : AMCOP elastodontic devices effectively promote anterior mandibular rotation and reduce mandibular plane inclination in hyperdivergent patients, contributing to balanced craniofacial growth. The expansion of pharyngeal spaces indicates potential respiratory benefits. Future research is needed to confirm long-term stability and address variability in treatment response.