太空飞行会导致形成有缺陷的骨骼。

Spaceflight results in formation of defective bone.

作者信息

Turner R T, Bell N H, Duvall P, Bobyn J D, Spector M, Holton E M, Baylink D J

出版信息

Proc Soc Exp Biol Med. 1985 Dec;180(3):544-9. doi: 10.3181/00379727-180-42215.

Abstract

Growing rats were flown on 19 day spaceflights aboard Cosmos 782 and 936 biosatellites. Spaceflight resulted in a prominent skeletal defect at the periosteal surface of the tibia diaphysis. The defect, termed an arrest line, was approximately 3 micron across and separated the bone formed in space from that formed following spaceflight. The bone matrix at the arrest line region was abnormal in that collagen fibers were preferentially orientated parallel to the periosteal surface. In addition, the bone matrix was hypomineralized. The altered bone was inferior to normal bone in resistance to abrasion and may be partially responsible for the decrease in torsional strength observed after spaceflight.

摘要

正在生长的大鼠搭乘“宇宙782号”和“宇宙936号”生物卫星进行了为期19天的太空飞行。太空飞行导致胫骨骨干骨膜表面出现明显的骨骼缺陷。这种缺陷被称为停滞线，宽度约为3微米，将太空形成的骨骼与太空飞行后形成的骨骼分隔开来。停滞线区域的骨基质异常，因为胶原纤维优先平行于骨膜表面排列。此外，骨基质矿化不足。这种改变后的骨骼在耐磨性方面不如正常骨骼，可能是太空飞行后观察到的抗扭强度下降的部分原因。