Faris P L
Prog Clin Biol Res. 1985;192:159-66.
Intraperitoneal administration of cholecystokinin (CCK) potently attenuated opiate analgesia produced by footshock. CCK also inhibited opiate footshock analgesia when delivered intrathecally to the lumbosacral spinal cord, a critical site of opiate action in mediating this form of analgesia. However, opiate-independent footshock analgesia was not attenuated by CCK. Morphine analgesia was attenuated by CCK and potentiated by sequestration of peripheral CCK through an active immunization procedure. CCK also was found to suppress food intake in rats when microinjected into the hypothalamic paraventricular nucleus, a site known to mediate opiate-induced feeding. Collectively, the findings reviewed here suggest that an opiate antagonistic action may underlie several of the effects of CCK.
腹腔注射胆囊收缩素（CCK）可有效减弱足部电击产生的阿片类镇痛作用。当鞘内注射至腰骶脊髓时，CCK也能抑制阿片类足部电击镇痛作用，而腰骶脊髓是阿片类药物介导这种镇痛形式的关键作用部位。然而，CCK并未减弱非阿片类足部电击镇痛作用。CCK可减弱吗啡镇痛作用，而通过主动免疫程序隔离外周CCK则可增强吗啡镇痛作用。当微量注射到下丘脑室旁核（已知该部位介导阿片类药物引起的进食）时，CCK也被发现可抑制大鼠的食物摄入。总体而言，此处综述的研究结果表明，阿片类拮抗作用可能是CCK多种效应的基础。
