Erdei Eszter, Mándoki András, Deák Andrea, Balogh Balázs, Molnár László, Mándity István M
Institute of Organic Chemistry, Semmelweis University, Hőgyes Endre u. 7, H-1092 Budapest, Hungary.
Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar Tudósok krt. 2, H-1117 Budapest, Hungary.
Molecules. 2025 Aug 7;30(15):3310. doi: 10.3390/molecules30153310.
Interest in gold nanoclusters (AuNCs) has grown significantly in recent decades. AuNCs, with a core size smaller than 2 nm, represent a unique class of functional nanomaterials. Their distinctive properties enable innovative applications across various interdisciplinary fields. Here, we introduce BioGoldNCDB, a freely available, fully annotated, and manually curated database of mainly about AuNCs and related AuNPs. Despite the rapid growth in biomedical applications of gold nanoclusters (AuNCs), the lack of a centralized and structured data resource hinders comparative analysis and rational design. Researchers face challenges in accessing standardized information on AuNCs' structures, properties, and biological activities, which limits data-driven development in this emerging field. The database provides essential information, including CAS numbers and PubMed IDs, as well as specific details such as biomedical applications, cell lines used in research, particle size, and excitation/emission wavelengths. It currently covers 247 articles from 104 journals. Designed with a user-friendly and intuitive web interface, BioGoldNCDB is accessible on multiple devices, including phones, tablets, and PCs. Users can refine searches with multiple filters, and a help page is available for guidance. While offering quick insights for newcomers, BioGoldNCDB also serves as a valuable resource for researchers across various fields.
近几十年来，人们对金纳米团簇（AuNCs）的兴趣显著增长。核心尺寸小于2纳米的金纳米团簇代表了一类独特的功能性纳米材料。它们独特的性质使得在各个跨学科领域都能有创新应用。在此，我们介绍BioGoldNCDB，这是一个免费提供、全面注释且人工整理的数据库，主要收录有关金纳米团簇及相关金纳米颗粒（AuNPs）的信息。尽管金纳米团簇（AuNCs）在生物医学应用方面迅速发展，但缺乏一个集中且结构化的数据资源阻碍了比较分析和合理设计。研究人员在获取有关金纳米团簇的结构、性质和生物活性的标准化信息时面临挑战，这限制了这一新兴领域中数据驱动的发展。该数据库提供了基本信息，包括化学物质登记号（CAS号）和医学期刊数据库（PubMed）的识别码，以及诸如生物医学应用、研究中使用的细胞系、粒径和激发/发射波长等具体细节。它目前涵盖了来自104种期刊的247篇文章。BioGoldNCDB设计了用户友好且直观的网络界面，可在包括手机、平板电脑和个人电脑在内的多种设备上访问。用户可以使用多个筛选条件来优化搜索，并且有一个帮助页面可供指导。BioGoldNCDB在为新手提供快速见解的同时，也为各个领域的研究人员提供了宝贵的资源。
