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提高生物活性化合物的稳定性:通过喷雾干燥进行微囊化及其物理化学评估

Enhancing Stability of Bioactive Compounds: Microencapsulation via Spray-Drying and Its Physicochemical Evaluation.

作者信息

Fahrudin Fahmi Ilman, Phongthai Suphat, Intipunya Pilairuk

机构信息

Doctoral Degree Program in Food Science and Technology, Chiang Mai University, Chiang Mai 50100, Thailand.

Division of Food Science and Technology, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.

出版信息

Foods. 2025 Jul 31;14(15):2699. doi: 10.3390/foods14152699.

Abstract

This study aimed to microencapsulate (fingerroot) extract using maltodextrin (MD) and gum arabic (GA) as wall materials via spray-drying to improve powder physicochemical properties and protect bioactive compounds. MD and GA were employed as wall materials in varying ratios (MD:GA of 1:0, 0:1, 1:1, 2:1, 1:2) to evaluate their effects on the physicochemical properties of the resulting microcapsules. Spray-dried microcapsules were evaluated for morphology, flowability, particle size distribution, moisture content, hygroscopicity, solubility, encapsulation efficiency, major bioactive compound retention, and thermal stability. The extract encapsulation using MD:GA at 1:1 ratio (MD1GA1) demonstrated a favorable balance, with high solubility (98.70%), low moisture content (8.69%), low hygroscopicity (5.08%), and uniform particle morphology, despite its moderate EE (75.06%). SEM images revealed spherical particles with fewer surface indentations in MD-rich formulations. Microencapsulation effectively retained pinostrobin and pinocembrin in all formulations with pinostrobin consistently retained at a higher value, indicating its higher stability. The balanced profile of physical and functional properties of fingerroot extract with MD1GA1 microcapsule makes it a promising candidate for food and nutraceutical applications.

摘要

本研究旨在以麦芽糊精(MD)和阿拉伯胶(GA)为壁材,通过喷雾干燥法对(姜黄根)提取物进行微囊化处理,以改善粉末的物理化学性质并保护生物活性化合物。采用不同比例(MD:GA为1:0、0:1、1:1、2:1、1:2)的MD和GA作为壁材,以评估它们对所得微胶囊物理化学性质的影响。对喷雾干燥的微胶囊进行了形态、流动性、粒度分布、水分含量、吸湿性、溶解性、包封率、主要生物活性化合物保留率和热稳定性的评估。使用1:1比例的MD:GA(MD1GA1)对提取物进行包封表现出良好的平衡,具有高溶解性(98.70%)、低水分含量(8.69%)、低吸湿性(5.08%)和均匀的颗粒形态,尽管其包封率适中(75.06%)。扫描电子显微镜图像显示,富含MD的配方中有球形颗粒,表面凹痕较少。微囊化在所有配方中均有效地保留了松属素和松黄,其中松属素始终保持较高的值,表明其具有更高的稳定性。MD1GA1微胶囊的姜黄根提取物在物理和功能特性方面的平衡特性使其成为食品和营养保健品应用的有前途的候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92dc/12346394/99f0bd707822/foods-14-02699-g001.jpg

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