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挖掘金作为癌症免疫疗法中纳米药物的潜力。

Unlocking the Potential of Gold as Nanomedicine in Cancer Immunotherapy.

作者信息

Kumar Panangattukara Prabhakaran Praveen, Lee Maggie, Kim Taeho

机构信息

Department of Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.

出版信息

J Nanotheranostics. 2024 Jun;5(2):29-59. doi: 10.3390/jnt5020003. Epub 2024 Apr 30.

DOI:10.3390/jnt5020003
PMID:40808797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12346115/
Abstract

Nanotechnology advancements have resulted in many sensors and devices for biomedical applications. Among the various nanomaterials, gold nanoparticles (AuNPs), due to their size, shape, biocompatibility, and unique plasmonic property, are an excellent candidate for many biomedical applications. AuNPs, known for their easy surface modifications, robust nature, and photothermal activities, find application in drug delivery and cancer treatment studies. In this review, we are highlighting the recent trends in using AuNPs as nanomedicine for cancer immunotherapy. Cancer immunotherapy not only eliminates the primary tumors but also allows for the treatment of metastasis along with the recurrence of the tumor. AuNPs possess tissue-specific delivery functions that depend on the tunability in size and surface functionalization of AuNPs. AuNPs can be used to activate the tumor's immune defense ability, or they can be used to enhance the anti-tumor immune response. Understanding the interaction of the tumor environment and nanobiomedicine is very important. In the present review, we give an idea of the mode of action of AuNPs and various combinations of therapies for cancer immunotherapy.

摘要

纳米技术的进步催生了许多用于生物医学应用的传感器和设备。在各种纳米材料中，金纳米颗粒（AuNPs）因其尺寸、形状、生物相容性和独特的等离子体特性，成为许多生物医学应用的理想选择。AuNPs以其易于表面修饰、稳定性和光热活性而闻名，在药物递送和癌症治疗研究中得到应用。在本综述中，我们重点介绍了将AuNPs用作癌症免疫治疗纳米药物的最新趋势。癌症免疫治疗不仅可以消除原发性肿瘤，还可以治疗转移以及肿瘤复发。AuNPs具有组织特异性递送功能，这取决于AuNPs尺寸的可调节性和表面功能化。AuNPs可用于激活肿瘤的免疫防御能力，也可用于增强抗肿瘤免疫反应。了解肿瘤环境与纳米生物医学之间的相互作用非常重要。在本综述中，我们介绍了AuNPs的作用模式以及用于癌症免疫治疗的各种联合疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3544/12346115/368402c4f16f/nihms-2052057-f0010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3544/12346115/26bbc7196d81/nihms-2052057-f0009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3544/12346115/e271486d7f36/nihms-2052057-f0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3544/12346115/4ea671544eec/nihms-2052057-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3544/12346115/79edac14c64a/nihms-2052057-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3544/12346115/e0ff57206b70/nihms-2052057-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3544/12346115/0e7d6fb4d267/nihms-2052057-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3544/12346115/26bbc7196d81/nihms-2052057-f0009.jpg
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