Hua Jianfeng, Wu Pan, Gan Lu, Zhang Zhikun, He Jian, Zhong Liping, Zhao Yongxiang, Huang Yong
National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, China.
The First People's Hospital of Changde City, Changde, China.
Front Oncol. 2021 Nov 17;11:738323. doi: 10.3389/fonc.2021.738323. eCollection 2021.
Photodynamic therapy (PDT) is a low invasive antitumor therapy with fewer side effects. On the other hand, immunotherapy also has significant clinical applications in the treatment of cancer. Both therapies, on their own, have some limitations and are incapable of meeting the demands of the current cancer treatment. The efficacy of PDT and immunotherapy against tumor metastasis and tumor recurrence may be improved by combination strategies. In this review, we discussed the possibility that PDT could be used to activate immune responses by inducing immunogenic cell death or generating cancer vaccines. Furthermore, we explored the latest advances in PDT antitumor therapy in combination with some immunotherapy such as immune adjuvants, inhibitors of immune suppression, and immune checkpoint blockade.
光动力疗法（PDT）是一种低侵入性的抗肿瘤疗法，副作用较少。另一方面，免疫疗法在癌症治疗中也有重要的临床应用。这两种疗法各自都有一些局限性，无法满足当前癌症治疗的需求。联合策略可能会提高光动力疗法和免疫疗法在抗肿瘤转移和肿瘤复发方面的疗效。在本综述中，我们探讨了光动力疗法通过诱导免疫原性细胞死亡或生成癌症疫苗来激活免疫反应的可能性。此外，我们还探索了光动力疗法与一些免疫疗法（如免疫佐剂、免疫抑制抑制剂和免疫检查点阻断）联合进行抗肿瘤治疗的最新进展。
