An Jia, Wang Qiang, Bai Zihao, Ma Siyu, Yang Zhaocong, Yu Di, Mo Xuming
Nanjing Children's Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Nanjing, China.
Department of Cardio-Thoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
Front Microbiol. 2025 Jul 30;16:1639057. doi: 10.3389/fmicb.2025.1639057. eCollection 2025.
Neurodevelopmental disorder (ND) has emerged as a critical factor affecting the long-term quality of life among patients with congenital heart disease (CHD). The aim of this study was to provide a multi-omics perspective on the mechanisms of ND.
We analyzed the serum metabolome and gut microbiome of children with ND and non-ND (NND) in CHD populations.
In this prospective observational study, we identified associations between serum metabolites, gut microbial, and ND. Linolenic acid was most closely related to neurodevelopmental outcomes, showing positive correlations with multiple neurodevelopmental domains. Among the gut microbiota, the Escherichia genus was most strongly associated with neurodevelopmental outcomes, and negative correlations with neurodevelopmental domains.
This multi-omics study reveals significant association between altered serum metabolites, gut microbiota dysbiosis, and neurodevelopmental outcomes in children with CHD. The microbes and metabolites identified here may contribute to addressing the challenge of ND in the CHD population. Based on our findings, therapeutic strategies to reduce the risk of ND could be developed, including targeted manipulation of the gut microbiota and metabolites.
神经发育障碍（ND）已成为影响先天性心脏病（CHD）患者长期生活质量的关键因素。本研究旨在从多组学角度探讨ND的发病机制。
我们分析了CHD患者中患ND和未患ND（NND）儿童的血清代谢组和肠道微生物组。
在这项前瞻性观察研究中，我们确定了血清代谢物、肠道微生物与ND之间的关联。亚麻酸与神经发育结局关系最为密切，与多个神经发育领域呈正相关。在肠道微生物群中，埃希氏菌属与神经发育结局关联最为强烈，与神经发育领域呈负相关。
这项多组学研究揭示了CHD患儿血清代谢物改变、肠道微生物群失调与神经发育结局之间存在显著关联。此处鉴定出的微生物和代谢物可能有助于应对CHD人群中ND的挑战。基于我们的研究结果，可制定降低ND风险的治疗策略，包括对肠道微生物群和代谢物进行靶向调控。
