全身免疫炎症指数与潜伏性结核感染之间的关联：一项横断面研究。

Association between systemic immune-inflammation index and latent tuberculosis infection: a cross-sectional study.

作者信息

Pang Ting, Wang Lei, Zhang Jie, Duan Shuhong

机构信息

Department of Infectious Diseases, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

出版信息

Front Med (Lausanne). 2025 Jul 30;12:1615302. doi: 10.3389/fmed.2025.1615302. eCollection 2025.

DOI:10.3389/fmed.2025.1615302

PMID:40809440

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12343535/

Abstract

BACKGROUND

The systemic immune-inflammation index (SII) has been associated with various diseases, but its relationship with latent tuberculosis infection (LTBI) remains unclear. This study aimed to evaluate the association between SII and LTBI in United States adults.

METHODS

Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 and 2011-2012 cycles. LTBI was defined as a positive result on either the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay or the tuberculin skin test (TST). SII was calculated based on neutrophil, platelet, and lymphocyte counts. All analyses were performed using complex survey design and sampling weights. Multivariable logistic regression models were applied to evaluate the association between SII and LTBI. SII was also analyzed in quartiles to assess trends. Restricted cubic spline (RCS) was employed to explore the potential non-linear associations. Subgroup analyses were conducted to assess whether the association varied across demographic and clinical strata.

RESULTS

A total of 9,489 participants were included, among whom 1,068 were identified with LTBI. Multivariable logistic regression demonstrated that SII was inversely associated with LTBI. For each 100-unit increase in SII, the odds of LTBI decreased by 6% (adjusted OR = 0.94, 95% CI: 0.90-0.97). When analyzed by quartiles, participants in the highest quartile had significantly lower odds of LTBI compared to those in the lowest quartile (adjusted OR = 0.58, 95% CI: 0.41-0.81), with a significant trend across quartiles ( for trend = 0.003). RCS showed a linear relationship between SII/100 and LTBI ( for non-linearity >0.05). The results of further subgroups analysis were consistent, with a significant interaction observed only for HIV status ( for interaction = 0.034).

CONCLUSION

SII was inversely associated with LTBI and may serve as a readily accessible marker for LTBI risk stratification. Given its non-specific nature, further longitudinal studies are needed to validate its clinical and public health utility.

摘要

背景

全身免疫炎症指数（SII）已与多种疾病相关，但它与潜伏性结核感染（LTBI）的关系仍不清楚。本研究旨在评估美国成年人中SII与LTBI之间的关联。

方法

数据来自1999 - 2000年和2011 - 2012年周期的美国国家健康与营养检查调查（NHANES）。LTBI被定义为结核感染T细胞检测（QFT - GIT）或结核菌素皮肤试验（TST）结果为阳性。SII根据中性粒细胞、血小板和淋巴细胞计数计算得出。所有分析均采用复杂抽样设计和抽样权重进行。应用多变量逻辑回归模型评估SII与LTBI之间的关联。SII也按四分位数进行分析以评估趋势。采用受限立方样条（RCS）来探索潜在的非线性关联。进行亚组分析以评估该关联在不同人口统计学和临床分层中是否存在差异。

结果

共纳入9489名参与者，其中1068人被确定为LTBI。多变量逻辑回归表明SII与LTBI呈负相关。SII每增加100个单位，LTBI的患病几率降低6%（调整后的OR = 0.94，95%CI：0.90 - 0.97）。按四分位数分析时，最高四分位数的参与者患LTBI的几率显著低于最低四分位数的参与者（调整后的OR = 0.58，95%CI：0.41 - 0.81），四分位数间存在显著趋势（趋势检验P = 0.003）。RCS显示SII/100与LTBI之间呈线性关系（非线性检验P>0.05）。进一步亚组分析结果一致，仅在HIV状态方面观察到显著的交互作用（交互作用检验P = 0.034）。