Wang Crystal X, Letendre Scott L, Hong Suzi, Andalibi Mohammad, Iudicello Jennifer E, Ellis Ronald J
Department of Psychiatry.
Department of Medicine.
AIDS. 2025 Apr 1;39(5):554-559. doi: 10.1097/QAD.0000000000004088. Epub 2024 Dec 12.
HIV infection is linked to persistent inflammation despite effective antiretroviral therapy (ART). The Systemic Immune-Inflammation Index (SII) is a marker of inflammation in various conditions.
We compared SII values between PWH and PWoH. Clinical blood laboratory data were used to calculate the SII for each participant using the formula [(Platelet count × Neutrophil count)/Lymphocyte count]. Differences in SII values between the groups were analyzed using the Wilcoxon test, and the impact of potential confounders was assessed with multivariable regression models.
The study included 343 PWH and 199 PWoH. Age and race did not significantly differ, but sex distribution did (83.1% male in PWH vs. 55.8% in PWoH, P < 0.0001). Among PWH, median [IQR] nadir and current CD4 + cell counts were 199 cells/μl [50, 350] and 650 [461,858], respectively. Nearly all PWH were on ART, with 97.2% achieving viral suppression. PWH had lower SII values than PWoH (327 [224, 444] vs. 484 [335,657], P = 1.35e-14). PWH also had lower neutrophils and platelets ( P s < 0.001) and higher lymphocyte counts ( P = 0.001). These differences remained significant after adjusting for age, sex, and other potential confounders.
Contrary to expectations, PWH had lower SII levels, likely due to altered hematologic parameters influenced by HIV and ART. These findings suggest that SII interpretation in PWH requires consideration of unique hematologic profiles and underscore the need for further research to understand the mechanisms and clinical implications of SII in HIV management.
尽管接受了有效的抗逆转录病毒疗法（ART），但HIV感染仍与持续性炎症相关。全身免疫炎症指数（SII）是各种情况下炎症的标志物。
我们比较了HIV感染者（PWH）和未感染HIV者（PWoH）的SII值。使用临床血液实验室数据，通过公式[（血小板计数×中性粒细胞计数）/淋巴细胞计数]计算每位参与者的SII。使用Wilcoxon检验分析两组之间SII值的差异，并通过多变量回归模型评估潜在混杂因素的影响。
该研究纳入了343名PWH和199名PWoH。年龄和种族无显著差异，但性别分布有差异（PWH中男性占83.1%，PWoH中男性占55.8%，P<0.0001）。在PWH中，最低点和当前CD4+细胞计数的中位数[四分位间距]分别为199个细胞/μl[50,350]和650[461,858]。几乎所有PWH都在接受ART治疗，97.2%实现了病毒抑制。PWH的SII值低于PWoH（327[224,444]对484[335,657]，P=1.35e-14）。PWH的中性粒细胞和血小板也较低（P<0.001），淋巴细胞计数较高（P=0.001）。在调整年龄、性别和其他潜在混杂因素后，这些差异仍然显著。
与预期相反，PWH的SII水平较低，可能是由于受HIV和ART影响的血液学参数改变。这些发现表明，在PWH中解释SII需要考虑独特的血液学特征，并强调需要进一步研究以了解SII在HIV管理中的机制和临床意义。
