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Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications?过量叶酸和维生素 B12 缺乏:临床意义?
Food Nutr Bull. 2024 Jun;45(1_suppl):S67-S72. doi: 10.1177/03795721241229503.
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Scientific opinion on the tolerable upper intake level for preformed vitamin A and β-carotene.关于预形成维生素A和β-胡萝卜素可耐受最高摄入量的科学意见。
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Evaluation of isotretinoin effects on depression, sleep apnea and sleep quality.评估异维 A 酸对抑郁、睡眠呼吸暂停和睡眠质量的影响。
Cutan Ocul Toxicol. 2024 Jun;43(2):129-133. doi: 10.1080/15569527.2024.2340435. Epub 2024 Apr 17.
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The occurrence of mental health symptoms in isotretinoin-treated adolescents.异维 A 酸治疗的青少年出现心理健康症状。
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Vitamin B6 Toxicity Secondary to Daily Multivitamin Use: A Case Report.每日服用多种维生素继发维生素B6中毒:一例报告
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Face-to-face: isotretinoin use and pregnancy outcome.面对面:异维 A 酸的使用与妊娠结局。
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Risk of Suicide and Psychiatric Disorders Among Isotretinoin Users: A Meta-Analysis.异维 A 酸使用者的自杀风险和精神障碍:一项荟萃分析。
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Scientific opinion on the tolerable upper intake level for folate.关于叶酸可耐受最高摄入量的科学意见。
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过量维生素A、B6和叶酸对神经系统的毒性作用

Toxic Effects of Excess Vitamins A, B6, and Folic Acid on the Nervous System.

作者信息

Sun Yu, Yu Xiaofeng, Teng Yiliang, Sun Yanping

机构信息

Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Department of Neurology, Qingdao Eighth People's Hospital, Qingdao, China.

出版信息

Behav Neurol. 2025 Aug 6;2025:7888243. doi: 10.1155/bn/7888243. eCollection 2025.

DOI:10.1155/bn/7888243
PMID:40809450
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12350011/
Abstract

As one of the seven primary nutrients in the human body, vitamins are vital to maintaining good health. In recent years, there has been a completely new understanding of vitamins, and researchers have conducted more thorough investigations on them. These compounds, once viewed simply as supplemental nutrients, are now believed to play a more complex and critical role in human health. On the other hand, ingesting too much vitamins may cause negative health effects. Multiple studies have demonstrated a strong correlation between neurological problems and excessive vitamin intake. The purpose of this paper is to review the toxic effects of excessive vitamin intake on the nervous system, focusing on vitamin A and some of the B vitamins. It also analyzes the relationship between excessive vitamin intake and neurological dysfunction by reviewing the research findings in recent years, mainly including their possible mechanisms of action, clinical manifestations, and preventive measures, to provide ideas and inspiration for the subsequent clinical research.

摘要

作为人体七大主要营养素之一,维生素对维持身体健康至关重要。近年来,人们对维生素有了全新的认识,研究人员也对其进行了更深入的研究。这些曾经仅仅被视为补充性营养素的化合物,如今被认为在人类健康中发挥着更为复杂和关键的作用。另一方面,摄入过多维生素可能会对健康产生负面影响。多项研究表明,神经问题与过量摄入维生素之间存在密切关联。本文旨在综述过量摄入维生素对神经系统的毒性作用,重点关注维生素A和一些B族维生素。通过回顾近年来的研究结果,分析过量摄入维生素与神经功能障碍之间的关系,主要包括其可能的作用机制、临床表现及预防措施,为后续的临床研究提供思路和启示。