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[辐照去交感神经大鼠的脑酶活性]

[Brain enzyme activity in irradiated sympathectomized rats].

作者信息

Pikulev A T, Kukulianskaia M F, Khripchenko I P, Gavriliuk L P, Pevzner I A

出版信息

Radiobiologiia. 1985 Nov-Dec;25(6):804-5.

PMID:4080998
Abstract

The results are reviewed from studies of activity of hexokinase (2.7.1.1.EC), dehydrogenase glucose-6-phosphate (1.1.1.49 EC), and cholinesterase (3.1.1.7 EC) in subcellular fractions of rat brain at the background of chemical sympathectomy induced by long-term administration of guanethidine and subsequent irradiation with a dose of 7 Gy. In conditions of sympathectomy, the enzyme activity is inhibited; in irradiated sympathectomized rats, activity of hexokinase and cholinesterase increases to reach the level of that of intact animals while dehydrogenase remains inhibited.

摘要

对长期给予胍乙啶诱导化学性交感神经切除并随后接受7戈瑞剂量照射的大鼠脑亚细胞组分中己糖激酶(EC 2.7.1.1)、6-磷酸葡萄糖脱氢酶(EC 1.1.1.49)和胆碱酯酶(EC 3.1.1.7)活性的研究结果进行了综述。在交感神经切除的情况下,酶活性受到抑制;在接受照射的交感神经切除大鼠中,己糖激酶和胆碱酯酶的活性增加,达到完整动物的水平,而脱氢酶仍受到抑制。

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