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用于自适应光学扫描激光检眼镜中提高分辨率和焦深的轴棱锥。

Axicons for improved resolution and depth of focus in adaptive optics scanning light ophthalmoscopy.

作者信息

Woehlke Ruth E, Cooper Robert F

机构信息

Joint Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Department of Ophthalmology and Visual Science, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

出版信息

Biomed Opt Express. 2025 Jul 16;16(8):3172-3193. doi: 10.1364/BOE.564398. eCollection 2025 Aug 1.

Abstract

Adaptive optics scanning light ophthalmoscopes are instrumental for studying the eye, yet they use truncated Gaussian illumination and are limited by diffraction, restricting resolution and depth of focus (DOF). Non-diffractive Bessel beams have emerged as an alternative. Here, we use two axicons configured as: (1) an extended DOF beam for resolving multiple retinal layers; and (2) an annular beam for increasing lateral resolution. We compare both approaches to truncated Gaussian illumination using a variety of metrics. Using Configuration 1, we successfully observed multiple retinal layers simultaneously. Using Configuration 2, we observed enhanced lateral resolution but decreased signal-to-noise ratio.

摘要

自适应光学扫描激光检眼镜对于研究眼睛很有帮助,但它们使用截断高斯照明,并且受到衍射的限制,从而限制了分辨率和焦深(DOF)。非衍射贝塞尔光束已成为一种替代方案。在这里,我们使用两个配置为以下两种情况的轴锥镜:(1)一种用于分辨多个视网膜层的扩展焦深光束;(2)一种用于提高横向分辨率的环形光束。我们使用各种指标将这两种方法与截断高斯照明进行比较。使用配置1,我们成功地同时观察到了多个视网膜层。使用配置2,我们观察到横向分辨率提高,但信噪比降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1337/12339292/9a576d01b6af/boe-16-8-3172-g001.jpg

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