Watanabe Soh, Inamura Masanobu, Kodani Isamu
Department of Dentistry and Oral Surgery, Yoka Municipal Hospital, Yabu 667-8555.
Division of Oral and Maxillofacial Surgery, Tottori University Faculty of Medicine, Yonago 683-8504.
Yonago Acta Med. 2025 Jul 17;68(3):284-288. doi: 10.33160/yam.2025.08.008. eCollection 2025 Aug.
Polycythemia vera is a chronic myeloproliferative neoplasm characterized by a marked increase in circulating erythrocyte volume in middle-aged and elderly patients; it is associated with increased white blood cell and platelet counts and splenomegaly. There is a high risk of conflicting complications during surgical treatment, such as thrombosis and hemorrhage, with thrombosis being the leading cause of death. Hence, it is important to take measures against both in the perioperative management. We report a case of perioperative management of a patient with polycythemia vera and resection of an intraepithelial carcinoma of the tongue. The patient, a 46-year-old man, had been under observation at our hospital's Department of Internal Medicine for 10 years with a diagnosis of polycythemia vera. He came to our department with a complaint of white spots on the left tongue margin. Phlebotomy was performed when his blood count, hemoglobin, and hematocrit levels were elevated. The biopsy showed intraepithelial carcinoma. Preoperative examination revealed no abnormality, and a partial left-sided tongue resection was performed under general anesthesia. To prevent thromboembolism, the patient wore an elastic stocking from the time he entered the operating room. The patient underwent local hemostasis to prevent bleeding and systemic management centered on infusion therapy to prevent blood concentration. Four years and three months have passed since the surgery without recurrence.
真性红细胞增多症是一种慢性骨髓增殖性肿瘤,其特征是中年和老年患者循环红细胞体积显著增加;它与白细胞和血小板计数增加以及脾肿大有关。手术治疗期间存在血栓形成和出血等相互冲突的并发症的高风险,血栓形成是主要死因。因此,在围手术期管理中针对这两者采取措施很重要。我们报告一例真性红细胞增多症患者的围手术期管理及舌上皮内癌切除术。该患者为一名46岁男性,因诊断为真性红细胞增多症在我院内科观察了10年。他因左侧舌缘出现白斑前来我科就诊。当他的血细胞计数、血红蛋白和血细胞比容水平升高时,进行了放血治疗。活检显示为上皮内癌。术前检查未发现异常,在全身麻醉下进行了左侧舌部分切除术。为预防血栓栓塞,患者从进入手术室起就穿着弹力袜。患者进行了局部止血以防止出血,并以输液治疗为中心进行全身管理以防止血液浓缩。手术至今已过去四年零三个月,无复发。