Sheng Lingli, Cao Ziyi, Wang Lin, Xu Youhua, Gui Dingkun
Faculty of Chinese Medicine, Macau University of Science and Technology, Macao, Macao SAR, China.
Nephropathy Department II, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Endocrinol (Lausanne). 2025 Jul 30;16:1631312. doi: 10.3389/fendo.2025.1631312. eCollection 2025.
Diabetic kidney disease (DKD) is one of the most common and severe chronic microvascular complications of diabetes mellitus (DM). The pathogenesis of DKD is complex, and lipid metabolism disorders play an important role in the pathogenesis of DKD. DKD belongs to the category of "kidney deficiency", "edema", "guan ge" and other pathological factors secondary to "thirst quenching disease" in traditional Chinese medicine. The pathological factors mainly focus on blood stasis and toxicity, which is consistent with modern medical theory. At present, the efficacy and safety of integrated traditional Chinese and Western medicine in treating lipid metabolism disorders in patients with DKD have been extensively studied and confirmed. In this review, the application and possible mechanism of traditional Chinese patent medicines (Bailing Capsule, Shenyan Kangfu Tablets, Jinshuibao Capsule, Huangkui Capsule, Yi-Shen-Hua-Shi granule, Shenmai injection), Chinese medicine compound (Tangshen Formula, Danggui Buxue Decoction, Tangshenkang), single Chinese medicine (Astragalus membranaceus, Panax notoginseng, Salvia miltiorrhiza) combined with Western medicine in the treatment of DKD with lipid metabolism disorder were discussed, in order to provide ideas for clinical diagnosis and treatment of patients with DKD with lipid metabolism disorder.
糖尿病肾病(DKD)是糖尿病(DM)最常见且严重的慢性微血管并发症之一。DKD的发病机制复杂,脂质代谢紊乱在DKD的发病机制中起重要作用。DKD在中医中属于继发于“消渴病”的“肾虚”“水肿”“关格”等病理范畴。病理因素主要集中在血瘀和毒,这与现代医学理论相符。目前,中西医结合治疗DKD患者脂质代谢紊乱的疗效和安全性已得到广泛研究和证实。在本综述中,探讨了中成药(百令胶囊、肾炎康复片、金水宝胶囊、黄葵胶囊、益肾化湿颗粒、参麦注射液)、中药复方(糖肾方、当归补血汤、糖肾康)、单味中药(黄芪、三七、丹参)联合西药治疗脂质代谢紊乱型DKD的应用及可能机制,以期为脂质代谢紊乱型DKD患者的临床诊治提供思路。