Lei Weihong, Li Jiahuan, Liu Yiyi, Wang Ying, Wu Qing
School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, China.
Department of Psychiatry, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.
Front Endocrinol (Lausanne). 2025 Jul 30;16:1605484. doi: 10.3389/fendo.2025.1605484. eCollection 2025.
Metabolic dysfunction-associated fatty liver disease (MAFLD) in lean individuals indicates metabolic dysfunction and elevates risks of metabolic and cardiovascular diseases. Thus far, no studies have specifically examined the prevalence and risk factors of MAFLD in lean individuals with bipolar disorder.
This retrospective study included 1,072 patients aged 18 to 60 years. Participants were classified into two groups based on their Body Mass Index (BMI): those with a BMI ≥24 kg/m² were categorized as overweight or obese, while those with a BMI <24 kg/m² were defined as lean. Data were extracted from inpatient records at the Anhui Mental Health Center.
MAFLD prevalence markedly differed between groups (lean: 10.5% . overweight/obese: 76.3%, p<0.001). Among lean BD patients, MAFLD-positive and MAFLD-negative subgroups significantly differed in: age, onset age, illness duration, BMI, ALT, key metabolic indices, marital status, diabetes, and hypertension. Stepwise binary logistic regression analysis revealed that fasting blood glucose level, triglyceride level, gamma-glutamyl transferase (GGT) level, female gender and diabetes status were significant risk factors for MAFLD, while high-density lipoprotein (HDL) level was identified as a protective factor.
MAFLD is clinically relevant in lean BD patients. Fasting blood glucose level, triglyceride level, GGT level, female gender, and diabetes status were significant risk factors for MAFLD, whereas HDL level was a significant protective factor. Given the potential harm of MAFLD, it is essential to enhance vigilance and underscore the necessity of monitoring MAFLD among individuals with bipolar disorder, especially those who are lean.
瘦人患代谢功能障碍相关脂肪性肝病（MAFLD）表明存在代谢功能障碍，并增加了代谢和心血管疾病的风险。迄今为止，尚无研究专门调查双相情感障碍瘦人MAFLD的患病率及危险因素。
这项回顾性研究纳入了1072例年龄在18至60岁之间的患者。根据体重指数（BMI）将参与者分为两组：BMI≥24kg/m²者被归类为超重或肥胖，而BMI<24kg/m²者被定义为瘦人。数据从安徽省精神卫生中心的住院记录中提取。
两组间MAFLD患病率差异显著（瘦人：10.5%，超重/肥胖者：76.3%，p<0.001）。在瘦的双相情感障碍患者中，MAFLD阳性和MAFLD阴性亚组在年龄、起病年龄、病程、BMI、谷丙转氨酶（ALT）、关键代谢指标、婚姻状况、糖尿病和高血压方面存在显著差异。逐步二元逻辑回归分析显示，空腹血糖水平、甘油三酯水平、γ-谷氨酰转移酶（GGT）水平、女性性别和糖尿病状态是MAFLD的显著危险因素，而高密度脂蛋白（HDL）水平是保护因素。
MAFLD在瘦的双相情感障碍患者中具有临床相关性。空腹血糖水平、甘油三酯水平、GGT水平、女性性别和糖尿病状态是MAFLD的显著危险因素，而HDL水平是显著的保护因素。鉴于MAFLD的潜在危害，必须提高警惕，并强调对双相情感障碍患者，尤其是瘦人进行MAFLD监测的必要性。
