Cao Huizhen, Zhong Jiangming, Chen Lili
Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
JAR Life. 2025 Aug 5;14:100024. doi: 10.1016/j.jarlif.2025.100024. eCollection 2025.
This study investigated the effect of 0.2 % chlorhexidine gluconate on oral microbiota dysbiosis in Alzheimer's disease (AD) and explored potential links between oral microbiota and cognition, offering new insights into its role in AD treatment.
We assessed the impact of 0.2 % chlorhexidine gluconate on the oral microbiota of patients with AD. One hundred patients were divided into two groups based on oral health score (using a cut-off of 8). Subgingival plaque samples were analyzed using 16S rRNA sequencing; no significant differences in bacterial composition were observed between groups at baseline.
Poor oral health correlated with higher oral health scores ( = 0.000), fewer teeth ( = 0.002), lower cognitive levels ( = 0.048), and a higher proportion of patients with diabetes ( = 0.032). After 24 weeks of treatment with 0.2 % chlorhexidine gluconate in a randomized controlled trial, subgingival plaques from 66 patients showed changes in and ( < 0.05). a and were identified as potential interventional targets.
Chlorhexidine gluconate effectively alters oral flora, reducing harmful bacteria. Targeting specific microbiota disturbances may offer a promising strategy to delay AD onset or slow its progression.
This research was registered with the Chinese Clinical Trial Registry (ChiCTR; Reference: ChiCTR2000032876). Registered: 14th of May 2020; http://www.chictr.org.cn/showprojen.aspx?proj=53555.
本研究调查了0.2%葡萄糖酸氯己定对阿尔茨海默病（AD）患者口腔微生物群失调的影响，并探讨了口腔微生物群与认知之间的潜在联系，为其在AD治疗中的作用提供了新的见解。
我们评估了0.2%葡萄糖酸氯己定对AD患者口腔微生物群的影响。根据口腔健康评分（采用8分的临界值）将100名患者分为两组。使用16S rRNA测序分析龈下菌斑样本；基线时两组之间的细菌组成未观察到显著差异。
口腔健康状况差与较高的口腔健康评分（=0.000）、较少的牙齿数量（=0.002）、较低的认知水平（=0.048）以及较高比例的糖尿病患者（=0.032）相关。在一项随机对照试验中，用0.2%葡萄糖酸氯己定治疗24周后，66名患者的龈下菌斑显示出和的变化（<0.05）。a和被确定为潜在的干预靶点。
葡萄糖酸氯己定有效地改变口腔菌群，减少有害细菌。针对特定的微生物群紊乱可能提供一种有前景的策略来延迟AD的发病或减缓其进展。
本研究已在中国临床试验注册中心注册（ChiCTR；注册号：ChiCTR2000032876）。注册时间：2020年5月14日；网址：http://www.chictr.org.cn/showprojen.aspx?proj=53555 。
