Molecular and Cellular Neuroscience Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana 500037, India.
Department of Pharmacology, Nims Institute of Pharmacy, Nims University Rajasthan, Jaipur, India.
Ageing Res Rev. 2024 Nov;101:102481. doi: 10.1016/j.arr.2024.102481. Epub 2024 Sep 3.
Alzheimer's disease (AD) is the most common cause of dementia and accounts for 60-70 % of all cases. It affects millions of people worldwide. AD poses a substantial economic burden on societies and healthcare systems. AD is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. As the prevalence of AD continues to increase, understanding its pathogenesis, improving diagnostic methods, and developing effective therapeutics have become paramount. This comprehensive review delves into the intricate mechanisms underlying AD, explores the current state of diagnostic techniques, and examines emerging therapeutic strategies. By revealing the complexities of AD, this review aims to contribute to the growing body of knowledge surrounding this devastating disease.
阿尔茨海默病（AD）是痴呆症最常见的病因，占所有病例的 60-70%。它影响着全世界数以百万计的人。AD 给社会和医疗保健系统带来了巨大的经济负担。AD 是一种进行性神经退行性疾病，其特征是认知能力下降、记忆力丧失和日常功能受损。随着 AD 的患病率持续上升，了解其发病机制、改进诊断方法和开发有效的治疗方法变得至关重要。本综述深入探讨了 AD 的复杂机制，探讨了当前的诊断技术现状，并研究了新兴的治疗策略。通过揭示 AD 的复杂性，本综述旨在为围绕这一致命疾病的日益增长的知识体系做出贡献。
