Wang Zicheng, Fan Fei, Wang Yanfeng, Sun Junwei
IEEE Trans Comput Biol Bioinform. 2025 May-Jun;22(3):971-983. doi: 10.1109/TCBBIO.2025.3535701.
Biological circuits can not only be applied to ultra sensitive biomedical testing, but also provide new ideas for research in fields such as biomolecular information control, secure communication, and biological computers. In recent years, the synchronization of biological chaotic circuit (BCC) based on DNA strand displacement (DSD) has been widely studied and applied in the field of biological information secure communication. Therefore, this paper proposes a Q-S synchronization scheme of BCC based on DSD, and applies it to biological information secure communication. First, through the research and analysis of DNA molecular reaction dynamics and dual-rail representation, the ideal chemical reaction networks (CRNs) are realized, and the BCC is achieved through the cascade of CRNs. Second, the CRNs of synchronization controller are constructed according to the construction method of Q-S controller, and the combined synchronization between different variables of two BCC with different orders is realized. Finally, CRNs of biological information are designed, and secure communication and decryption of biological information are realized under Q-S synchronization scheme. The effectiveness and robustness of the scheme are proved by numerical simulation in software Visual DSD and MATLAB. Our work provides a new reference for the synchronization of BCC and the secure communication of biological information.
生物电路不仅可应用于超灵敏生物医学检测，还能为生物分子信息控制、安全通信和生物计算机等领域的研究提供新思路。近年来，基于DNA链置换（DSD）的生物混沌电路（BCC）同步在生物信息安全通信领域得到了广泛研究与应用。因此，本文提出一种基于DSD的BCC的Q-S同步方案，并将其应用于生物信息安全通信。首先，通过对DNA分子反应动力学和双轨表示的研究分析，实现理想的化学反应网络（CRNs），并通过CRNs的级联实现BCC。其次，根据Q-S控制器的构造方法构建同步控制器的CRNs，实现两个不同阶次BCC不同变量之间的组合同步。最后，设计生物信息的CRNs，在Q-S同步方案下实现生物信息的安全通信和解密。通过在软件Visual DSD和MATLAB中的数值模拟验证了该方案的有效性和鲁棒性。我们的工作为BCC的同步和生物信息的安全通信提供了新的参考。
